GPI-anchored proteins at the node of Ranvier
| Autor: | Marilyne Labasque, Catherine Faivre-Sarrailh |
|---|---|
| Přispěvatelé: | Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2009 |
| Předmět: |
Glycosylphosphatidylinositols
MESH: Membrane Microdomains Biochemistry Myelin 0302 clinical medicine Structural Biology Paranode Contactin MESH: Animals Axon Lipid raft 0303 health sciences Node of Ranvier Cell adhesion molecule MESH: Glycosylphosphatidylinositols Cell biology medicine.anatomical_structure Intercellular Junctions lipids (amino acids peptides and proteins) MESH: Membrane Proteins Glycan MESH: Axons MESH: Biological Transport Biophysics Biology Models Biological 03 medical and health sciences Membrane Microdomains Ranvier's Nodes Genetics medicine Animals Humans TAG-1 [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] Molecular Biology Raft 030304 developmental biology MESH: Humans Endoplasmic reticulum MESH: Models Biological Membrane Proteins Biological Transport Cell Biology Axons Membrane protein nervous system biology.protein MESH: Ranvier's Nodes 030217 neurology & neurosurgery MESH: Intercellular Junctions |
| Zdroj: | FEBS Letters FEBS Letters, Wiley, 2010, 584 (9), pp.1787-92. ⟨10.1016/j.febslet.2009.08.025⟩ FEBS Letters, 2010, 584 (9), pp.1787-92. ⟨10.1016/j.febslet.2009.08.025⟩ |
| ISSN: | 1873-3468 0014-5793 |
| DOI: | 10.1016/j.febslet.2009.08.025⟩ |
| Popis: | International audience; Contactin and TAG-1 are glycan phosphatidyl inositol (GPI)-anchored cell adhesion molecules that play a crucial role in the organization of axonal subdomains at the node of Ranvier of myelinating fibers. Contactin and TAG-1 mediate axo-glial selective interactions in association with Caspr-family molecules at paranodes and juxtaparanodes, respectively. How membrane proteins can be confined in these neighbouring domains along the axon has been the subject of intense investigations. This review will specifically examine the properties conferred by the lipid microenvironment to regulate trafficking and selective association of these axo-glial complexes. Increasing evidences from genetic and neuropathological models point to a role of lipid rafts in the formation or stabilization of the paranodal junctions. |
| Databáze: | OpenAIRE |
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