Impact of double filtration plasmapheresis on adhesion molecules levels in patients with stable coronary heart disease after coronary stenting
| Autor: | Valerii V. Tishko, Andrei N. Belskih, Alexey A. Sokolov, Marina E. Meshkova, Andrei M. Ivanov, Tatyana S. Skorinova |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Urology Coronary Disease Hyperlipidemias 030204 cardiovascular system & hematology Coronary artery disease 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Restenosis Internal medicine Internal Medicine Humans Medicine 030212 general & internal medicine Endothelial dysfunction Aged Neointimal hyperplasia business.industry Cell adhesion molecule Percutaneous coronary intervention Plasmapheresis General Medicine Adhesion Middle Aged medicine.disease Lipids Treatment Outcome Selectins Cardiology Stents Cardiology and Cardiovascular Medicine business Cell Adhesion Molecules Biomarkers Selectin |
| Zdroj: | Atherosclerosis Supplements. 30:92-98 |
| ISSN: | 1567-5688 |
| DOI: | 10.1016/j.atherosclerosissup.2017.05.024 |
| Popis: | Objective and methods Endothelial dysfunction and inflammatory reaction at the site of damage plays a key role in the formation of neointimal hyperplasia, and in the progression of atherosclerosis. The initiating role in these processes is assigned to adhesion molecules. We studied the dynamics of the level of adhesion molecules soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular adhesion molecule-1 (sVCAM-1), soluble form of the molecule platelet adhesion and endothelial type-1 (sPECAM-1), sL-, sP-, sE-selectins during double filtration plasmapheresis (DFPP) with use of plasma fractionators (PF) Cascadeflo EC-50W and EC-40W (Asahi Kasei Medical Co., Japan) in patients with stable coronary heart disease and hyperlipidemia-(a) in the early post-implantation period after coronary stenting. Results DFPP reduces the level of plasma adhesion molecules. When using PF Cascadeflo EC-40W, a more pronounced decrease occurs. The rejection coefficient (RC) of adhesion molecules has been identified for these PF. These RCs reflect the immediate removal efficiency of adhesion molecules in the perfusion of plasma through PF. The removal effectiveness of adhesion molecules when using PF Cascadeflo EC-40W is higher than when using the PF Cascadeflo EC-50W (sICAM-1 – 2.5 times, sVCAM-1 – 2.2 times, sPECAM-1.6 times, sL-selectin – 5 times, sP-selectin – 2.8 times, sE – selectin – 3 times). Conclusion Reducing adhesion molecule levels when using DFPP may play an important role in correcting of endothelial dysfunction in response to damage to the arterial wall in percutaneous coronary intervention (PCI) during the early post-implantation period after coronary stenting. DFPP is a promising approach to prevent in-stent restenosis (ISR). |
| Databáze: | OpenAIRE |
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