Forskolin: upcoming antiglaucoma molecule
| Autor: | Vijay D. Wagh, PN Patil, SJ Surana, Kalpana V. Wagh |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pharmaceutical drug
Drug Antiglaucoma drug medicine.medical_specialty genetic structures medicine.medical_treatment media_common.quotation_subject lcsh:Medicine India Cyclase Plant Roots law.invention forskolin chemistry.chemical_compound law Internal medicine Coleus medicine Animals Humans Cyclic adenosine monophosphate Drug Interactions coleus forskohlii Intraocular Pressure media_common Forskolin business.industry Plant Extracts lcsh:R Colforsin Glaucoma General Medicine Epinephrine Endocrinology chemistry Drug delivery nanoparticles Rabbits business Phytotherapy ophthalmic insert medicine.drug |
| Zdroj: | Journal of Postgraduate Medicine, Vol 58, Iss 3, Pp 199-202 (2012) |
| ISSN: | 0972-2823 |
| Popis: | Forskolin is the first pharmaceutical drug and product derived from a plant to be approved in India by the DCGI in 2006. Forskolin (7beta-acetoxy-8, 13-epoxy-1a, 6β, 9a-trihydroxy-labd-14-en-11-one) is a diterpenoid isolated from plant Coleus forskohlii (Lamiaceae). It is a lipid-soluble compound that can penetrate cell membranes and stimulates the enzyme adenylate cyclase which, in turn, stimulates ciliary epithelium to activate cyclic adenosine monophosphate, which decreases intraocular pressure (IOP) by reducing aqueous humor inflow. The topical application of forskolin is capable of reducing IOP in rabbits, monkeys, and humans. In its drug interactions, forskolin may act synergistically with epinephrine, ephedrine and pseudoephedrine. Whereas the effects of anti-clotting medications like warfarin, clopidogre, aspirin, anoxaparin, etc., may be enhanced by forskolin. Forskolin is contraindicated in the medications for people with ulcers as forskolin may increase acid level. Forskolin has a very good shelf-life of five years. Recently, its Ophthalmic inserts and in situ gels for sustained and delayed-release drug delivery systems were tested in New Zealand Albino Rabbits for its antiglaucoma efficacy. This drug review explains Forskolin as a drug, its antiglaucoma potential and recent findings of forskolin as an antiglaucoma agent. The literature search method used for this review was different databases and search engines like PubMed, International Pharmaceutical Abstracts, Google, Medicinal and Aromatic Plants (MAPA). |
| Databáze: | OpenAIRE |
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