Circling behaviour in rats with unilateral lesions of the nigrostriatum induced by 6-hydroxydopamine: Changes induced by oral administration of cytidine-5'-diphosphocholine☆
| Autor: | F. Boismare, N. Moore, C. Saligaut, M. Daoust |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Levodopa Cytidine Diphosphate Choline Apomorphine Administration Oral Pharmacology Choline Hydroxydopamines Cellular and Molecular Neuroscience chemistry.chemical_compound Dopamine medicine Animals Oxidopamine Amphetamine Hydroxydopamine Behavior Animal Tyrosine hydroxylase Chemistry Rats Inbred Strains Corpus Striatum Rats Substantia Nigra Dopamine receptor Anesthesia medicine.drug |
| Zdroj: | Neuropharmacology. 26:1315-1319 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/0028-3908(87)90093-1 |
| Popis: | A unilateral administration of 6-hydroxydopamine into the nigrostriatal system of the rat was responsible for ipsiversive circling behaviour in response to administration of amphetamine and, in time, of contraversive circling behaviour in response to l -DOPA and apomorphine. This contraversive circling behaviour appears to be mediated by the development, on the lesioned side, of supersensitivity of postsynaptic dopamine receptors. Subchronic treatment with cytidine-5'-diphosphocholine (p.o.) by itself was devoid of behavioural effects. The CDP-choline did not modify the apomorphine-induced stimulant effect but potentiated the circling behaviour produced by l -DOPA and amphetamine. The data show that the effects of CDP-choline were mediated by a presynaptic mechanism: the potentiation of the effects of l -DOPA cannot be explained by an activation of tyrosine hydroxylase, but seems to be related to an improvement of release of newly synthesized dopamine from exogenous l -DOPA. |
| Databáze: | OpenAIRE |
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