Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD)
| Autor: | Kai Förster, Hannah Marchi, Sophia Stöcklein, Olaf Dietrich, Harald Ehrhardt, Mark O. Wielpütz, Andreas W. Flemmer, Benjamin Schubert, Marcus A. Mall, Birgit Ertl-Wagner, Anne Hilgendorff |
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| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | American Journal of Physiology-Lung Cellular and Molecular Physiology. 324:L114-L122 |
| ISSN: | 1522-1504 1040-0605 |
| DOI: | 10.1152/ajplung.00430.2021 |
| Popis: | Neonatal chronic lung disease lacks standardized assessment of lung structural changes. We addressed this clinical need by the development of a novel scoring system [UNSEAL BPD (UNiforme Scoring of the disEAsed Lung in BPD)] using T2-weighted single-shot fast-spin-echo sequences from 3 T MRI in very premature infants with and without bronchopulmonary dysplasia (BPD). Quantification of interstitial and airway remodeling, emphysematous changes, and ventilation inhomogeneity was achieved by consensus scoring on a five-point Likert scale. We successfully identified moderate and severe disease by logistic regression [area under the curve (AUC), 0.89] complemented by classification tree analysis revealing gestational age-specific structural changes. We demonstrated substantial interreader reproducibility (weighted Cohen’s κ 0.69) and disease specificity (AUC = 0.91). Our novel MRI score enables the standardized assessment of disease-characteristic structural changes in the preterm lung exhibiting significant potential as a quantifiable endpoint in early intervention clinical trials and long-term disease monitoring. |
| Databáze: | OpenAIRE |
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