Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis
| Autor: | Liu Bm, You Bs, You Hy, Jun Yang, Liu Tm, Le-Qun Li, He Yc |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Xrcc1 arg399gln Polymorphism Single Nucleotide Gastroenterology Recessive inheritance Risk Factors Stomach Neoplasms Internal medicine Confidence Intervals Odds Ratio Genetics medicine Humans Genetic Predisposition to Disease Molecular Biology Genetic Association Studies business.industry General Medicine Odds ratio Confidence interval DNA-Binding Proteins X-ray Repair Cross Complementing Protein 1 Amino Acid Substitution Meta-analysis Dominant inheritance Cancer risk business Publication Bias |
| Zdroj: | Genetics and Molecular Research. 11:3852-3860 |
| ISSN: | 1676-5680 |
| DOI: | 10.4238/2012.november.12.2 |
| Popis: | Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive. We made a meta-analysis of 13 case-control studies, including 3278 cases and 6243 controls. Crude odds ratios (OR) with 95% confidence intervals (95%CI) were used to assess this possible association. We found no evidence of a significant association between the XRCC1 Arg399Gln polymorphism and gastric cancer risk (in the additive inheritance model, OR = 0.986, 95%CI = 0.831-1.156, in the dominant inheritance model, OR = 1.044, 95%CI = 0.890-1.224 and in the recessive inheritance model, OR = 0.975, 95%CI = 0.894-1.063). We conclude that the XRCC1 Arg399Gln polymorphism is not a risk factor for developing gastric cancer. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|