Resveratrol-Mediated Gold-Nanoceria Synthesis as Green Nanomedicine for Phytotherapy of Hepatocellular Carcinoma
| Autor: | Marcello Iriti, Sara Vitalini, Mohammad Ehsan Taghavizadeh Yazdi, Mohsen Qayoomian, Mohabat Nadaf, Fahimeh Nourbakhsh, Aliakbar Haddad-Mashadrizeh, Alireza Hashemzadeh, Mohammad Mashreghi, Mohammad Sadegh Amiri, Javad Mottaghipisheh, Adel Ghorani-Azam |
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| Rok vydání: | 2022 |
| Předmět: |
Carcinoma
Hepatocellular nanocomposite General Immunology and Microbiology green synthesis core-shells Liver Neoplasms cell toxicity cerium oxide nanogold Resveratrol Metal Nanoparticles General Medicine Cerium General Biochemistry Genetics and Molecular Biology Nanomedicine Humans Settore BIO/15 - Biologia Farmaceutica Gold Phytotherapy |
| Zdroj: | Frontiers in bioscience (Landmark edition). 27(8) |
| ISSN: | 2768-6698 |
| Popis: | In the present study, resveratrol was used to prepare complexes of cerium and nanoceria, also coated with gold (CeO2@Au core-shells) to improve the surface interactions in physiological conditions.The CeO2@Au core-shells were characterized using powder X-ray diffraction (PXRD), Fourier transforms infrared spectroscopy (FTIR), transmission electron microscope (TEM) analysis, dynamic light scattering (DLS) and ζ potential.The experiment was led to the successful synthesis of nanosized CeO2@Au core-shells, although agglomeration of particles caused the distribution of the larger particles. The TEM analysis demonstrated the particles sizes ranged from 20 nm to 170 nm. Moreover, the PXRD analysis showed that both nanoceria and gold with the same crystal systems and space groups. To investigate the anticancer activity of the CeO2@Au core-shells, the cytotoxicity of the nanoparticles was investigated against liver cancerous cell lines (HepG2).The results indicated biosynthesized NCs have significant cellular toxicity properties against HepG2 and could be utilized in hepatocarcinoma therapy. Further |
| Databáze: | OpenAIRE |
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