Effect of interglomerular inhibitory networks on olfactory bulb odor representations
| Autor: | Isaac A. Youngstrom, Matt Wachowiak, Daniel Zavitz, Alla Borisyuk |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Olfactory system Sensory system Olfaction Biology Inhibitory postsynaptic potential Mice 03 medical and health sciences Discrimination Psychological 0302 clinical medicine Lateral inhibition Neural Pathways medicine Animals Computer Simulation Axon 10. No inequality Research Articles 030304 developmental biology Glomerulus (olfaction) 0303 health sciences General Neuroscience Neural Inhibition Olfactory Pathways Olfactory Bulb Olfactory bulb Smell 030104 developmental biology medicine.anatomical_structure Odor Odorants Nerve Net Neuroscience Algorithms 030217 neurology & neurosurgery |
| Zdroj: | J Neurosci |
| DOI: | 10.1101/2020.03.03.975201 |
| Popis: | Lateral inhibition is a fundamental feature of circuits that process sensory information. In the mammalian olfactory system, inhibitory interneurons called short axon cells comprise the first network mediating lateral inhibition between glomeruli, the functional units of early olfactory coding and processing. The connectivity of this network and its impact on odor representations is not well understood. To explore this question, we constructed a computational model of the interglomerular inhibitory network using detailed characterizations of short axon cell morphologies taken from mouse olfactory bulb. We then examined how this network transformed glomerular patterns of odorant-evoked sensory input (taken from previously-published datasets) as a function of the selectivity of interglomerular inhibition. We examined three connectivity schemes: selective (each glomerulus connects to few others with heterogeneous strength), nonselective (glomeruli connect to most others with heterogenous strength) or global (glomeruli connect to all others with equal strength). We found that both selective and nonselective interglomerular networks could mediate heterogeneous patterns of inhibition across glomeruli when driven by realistic sensory input patterns, but that global inhibitory networks were unable to produce input-output transformations that matched experimental data and were poor mediators of intensity-dependent gain control. We further found that networks whose interglomerular connectivity was tuned by sensory input profile decorrelated odor representations more effectively. These results suggest that, despite their multiglomerular innervation patterns, short axon cells are capable of mediating odorant-specific patterns of inhibition between glomeruli that could, theoretically, be tuned by experience or evolution to optimize discrimination of particular odorants.Significance StatementLateral inhibition is a key feature of circuitry in many sensory systems including vision, audition, and olfaction. We investigate how lateral inhibitory networks mediated by short axon cells in the mouse olfactory bulb might shape odor representations as a function of their interglomerular connectivity. Using a computational model of interglomerular connectivity derived from experimental data, we find that short axon cell networks, despite their broad innervation patterns, can mediate heterogeneous patterns of inhibition across glomeruli, and that the canonical model of global inhibition does not generate experimentally observed responses to stimuli. In addition, inhibitory connections tuned by input statistics yield enhanced decorrelation of similar input patterns. These results elucidate how the organization of inhibition between neural elements may affect computations. |
| Databáze: | OpenAIRE |
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