Using miRNAs as diagnostic biomarkers for male infertility: opportunities and challenges
| Autor: | Ashutosh Vashisht, Gagandeep Kaur Gahlay |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Genetic Markers
Male 0301 basic medicine Embryology Idiopathic infertility Biology Candidate mirnas Bioinformatics Genome Male infertility 03 medical and health sciences 0302 clinical medicine microRNA Genetics medicine Animals Humans Diagnostic biomarker Spermatogenesis Molecular Biology Gene Infertility Male Epididymis Obstetrics and Gynecology Cell Biology medicine.disease MicroRNAs 030104 developmental biology Reproductive Medicine 030220 oncology & carcinogenesis MiRNA biogenesis Developmental Biology |
| Zdroj: | Molecular Human Reproduction. 26:199-214 |
| ISSN: | 1460-2407 |
| Popis: | The non-coding genome has been extensively studied for its role in human development and diseases. MicroRNAs (miRNAs) are small non-coding RNAs, which can regulate the expression of hundreds of genes at the post-transcriptional level. Therefore, any defects in miRNA biogenesis or processing can affect the genes and have been linked to several diseases. Male infertility is a clinical disorder with a significant number of cases being idiopathic. Problems in spermatogenesis and epididymal maturation, testicular development, sperm maturation or migration contribute to male infertility, and many of these idiopathic cases are related to issues with the miRNAs which tightly regulate these processes. This review summarizes the recent research on various such miRNAs and puts together the candidate miRNAs that may be used as biomarkers for diagnosis. The development of strategies for male infertility treatment using anti-miRs or miRNA mimics is also discussed. Although promising, the development of miRNA diagnostics and therapeutics is challenging, and ways to overcome some of these challenges are also reviewed. |
| Databáze: | OpenAIRE |
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