Dose-dependent effects of anthocyanin supplementation on platelet function in subjects with dyslipidemia: A randomized clinical trial

Autor: Zezhong Tian, Xiaoli Gao, Yimin Zhao, Ping Wang, Yan Yang, Kongyao Li, Lin Xu, Wenhua Ling, Yuheng Mao, Xilin Ma, Fuli Ya, Die Fan, Jinchao Zou, Yilin Shi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
BP
blood pressure

Medicine (General)
Platelet Aggregation
Apolipoprotein B
IPAQ
International Physical Activity Questionnaire

Fib
fibrinogen

PRP
platelet-rich plasma

HDL-C
high-density lipoprotein cholesterol

Anthocyanins
EDTA
ethylene diamine tetraacetic acid

chemistry.chemical_compound
WC
waist circumference

TT
thrombin clotting time

Platelet
ANOVA
analysis of variance

HR
heart rate

TG
triglyceride

biology
BW
body weight

food and beverages
General Medicine
Middle Aged
Malondialdehyde
Dose-dependent effects
UA
uric acid

P-Selectin
Randomized controlled trial
8-iso-PGF2α
8-iso-prostaglandin F2α

Medicine
Female
Platelet function
ASCVD
atherosclerotic cardiovascular disease

Research Paper
WHR
waist-hip ratio

Adult
medicine.medical_specialty
ApoA-1
apolipoprotein A-1

FBG
fasting blood glucose

HOMA-IR
insulin resistance

Platelet Glycoprotein GPIIb-IIIa Complex
SEM
standard error of the mean

Placebo
General Biochemistry
Genetics and Molecular Biology

ROS
reactive oxygen species

Insulin resistance
R5-920
PT
prothrombin time

Internal medicine
HC
hip circumference

medicine
Humans
ApoB
apolipoprotein B

APTT
activated partial thromboplastin time

Aged
Dyslipidemias
MDA
malondialdehyde

Dose-Response Relationship
Drug

business.industry
FINS
fasting insulin

BH
body height

medicine.disease
TC
total cholesterol

Endocrinology
TSOD
total superoxide dismutase

chemistry
Oxidative stress
Platelet-rich plasma
Dietary Supplements
biology.protein
Uric acid
LDL-C
low-density lipoprotein cholesterol

ACN
anthocyanin

Reactive Oxygen Species
business
NC
neck circumference

Platelet Aggregation Inhibitors
Dyslipidemia
Zdroj: EBioMedicine, Vol 70, Iss, Pp 103533-(2021)
EBioMedicine
ISSN: 2352-3964
Popis: BACKGROUND Dyslipidemia induces platelet hyperactivation and hyper-aggregation, which are linked to thrombosis. Anthocyanins could inhibit platelet function in vitro and in mice fed high-fat diets with their effects on platelet function in subjects with dyslipidemia remained unknown. This study aimed to investigate the effects of different doses of anthocyanins on platelet function in individuals with dyslipidemia. METHODS A double-blind, randomized, controlled trial was conducted. Ninety-three individuals who were initially diagnosed with dyslipidemia were randomly assigned to placebo or 40, 80, 160 or 320 mg/day anthocyanin groups. The supplementations were anthocyanin capsules (Medox, Norway). Platelet aggregation by light aggregometry of platelet-rich plasma, P-selectin, activated GPⅡbⅢa, reactive oxygen species (ROS), and mitochondrial membrane potential were tested at baseline, 6 weeks and 12 weeks. FINDINGS Compared to placebo group, anthocyanins at 80 mg/day for 12 weeks reduced collagen-induced platelet aggregation (-3.39±2.36%) and activated GPⅡbⅢa (-8.25±2.45%) (P
Databáze: OpenAIRE