A prospective, randomized, within-subject study of ALA-PDT for actinic keratoses using different irradiation regimes
| Autor: | John Paoli, Oscar Zaar, Martin Gillstedt, Alexandra Sjöholm Hylén |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Visual analogue scale medicine.medical_treatment Immunology Within person Pain Photodynamic therapy Dermatology law.invention 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law medicine Immunology and Allergy Humans Radiology Nuclear Medicine and imaging Irradiation Prospective Studies Pain Measurement business.industry General Medicine Actinic keratoses Light dose Keratosis Actinic Light intensity Photochemotherapy 030220 oncology & carcinogenesis Female business Nuclear medicine |
| Zdroj: | Photodermatology, photoimmunologyphotomedicine. 34(5) |
| ISSN: | 1600-0781 |
| Popis: | Background Photodynamic therapy (PDT) can be used to treat large fields of actinic keratoses (AKs) with high clearance rates. A notable downside is the amount of pain that accompany the treatment. This study aimed to optimize the illumination protocol during conventional PDT in order to reduce pain without compromising treatment effectiveness. Methods In this prospective, randomized study with a split-face design, patients with, symmetrically distributed AKs were included. All patients were treated using a ALA 78 mg/g gel. One side was illuminated with the Aktilite® CL-128 lamp and the other side with the RhodoLED® lamp in which the light intensity gradually increased to a maximum of 60%. Both sides received a total light dose of 37 J/cm2 . Pain during the treatment was measured using a visual analogue scale. The clinical effectiveness of the 2 treated sides was assessed after 12 weeks. Results Twenty-nine patients with 399 AKs were included. Illumination with the gradually increasing light intensity resulted in a decrease in the median visual analogue scale score by 1.1 points. Clearance rates were similar between the 2 lamps. Conclusion Minimizing the light intensity during the illumination phase of PDT reduces pain, while still preserving a high clearance rate of AKs. |
| Databáze: | OpenAIRE |
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