Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity

Autor:	Lin, Jonah, Law, Ryan, Korosec, Chapin S., Zhou, Christine, Koh, Wan Hon, Ghaemi, Mohammad Sajjad, Samaan, Philip, Ooi, Hsu Kiang, Matveev, Vitaliy, Yue, FengYun, Gingras, Anne-Claude, Estacio, Antonio, Buchholz, Megan, Cheatley, Patti Lou, Mohammadi, Avid, Kaul, Rupert, Pavinski, Katerina, Mubareka, Samira, McGeer, Allison J., Leis, Jerome A., Heffernan, Jane M., Ostrowski, Mario
Přispěvatelé:	Heise, Mark T.
Rok vydání:	2022
Předmět:	CD4-Positive T-Lymphocytes Male COVID-19 Vaccines Time Factors T cell immunity SARS-CoV-2 Immunology Immunity COVID-19 CD8-Positive T-Lymphocytes Microbiology Severity of Illness Index Interferon-gamma immune modeling ELISpot assay Virology Insect Science granzyme B Cytokines Humans Interleukin-2 Female Immunologic Memory
Zdroj:	Journal of virology. 96(13)
ISSN:	1098-5514
Popis:	Our findings highlight the relative importance of SARS-CoV-2-specific GzmB-producing T cell responses in SARS-CoV-2 control and shared CD4 and CD8 immunodominant epitopes in seasonal coronaviruses or SARS-CoV-1, and they indicate robust persistence of T cell memory at least 1 year after infection. Our findings should inform future strategies to induce T cell vaccines against SARS-CoV-2 and other coronaviruses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9288d342584376dff9baf31dafbfc162 https://pubmed.ncbi.nlm.nih.gov/35699447 Zobrazit plný text záznamu