The endocrinology of the menopausal transition: a cross-sectional study of a population-based sample
| Autor: | E C Dudley, J M Shelley, C Morse, Henry G. Burger, J L Hopper, Lorraine Dennerstein, A Smith, Adèle C. Green |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism media_common.quotation_subject Clinical Biochemistry Population Biology Biochemistry Follicle-stimulating hormone Endocrinology Sex hormone-binding globulin Internal medicine Endocrine Glands Sex Hormone-Binding Globulin medicine Humans Inhibins Testosterone education Menstrual cycle media_common education.field_of_study Estradiol Biochemistry (medical) Middle Aged medicine.disease Menopause Cross-Sectional Studies biology.protein Androgens Female Follicle Stimulating Hormone Luteinizing hormone Body mass index |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0021-972X |
| Popis: | In a study of the endocrinology of the perimenopausal years, levels of serum FSH, estradiol (E2), immunoreactive inhibin (INH), testosterone, and sex hormone-binding globulin were measured in a population-based sample of 380 women (mean age, 49.4 yr; range, 45.6-56.9 yr). Subjects were divided into women who reported continuing regular menstrual cycles (27%; group I), a change in menstrual flow without a change in frequency (23%; group II), a change in frequency but no change in flow (9%; group III), changes in both frequency and flow (28%; group IV), and at least 3 months since their last menstrual period (13%; group V). After adjusting for age and body mass index, the geometric mean FSH increased across menstrual groups and, compared with group I, was 53% higher in group IV (P < 0.0005) and 253% higher in group V (P < 0.0001). Age- and body mass index-adjusted geometric means for E2 and INH in group V were 54% and 53% of those in group 1, respectively (P < 0.005, P < 0.0001). Women in group V who did not have a menstrual period in the next year had higher FSH and lower E2 and INH levels than those who subsequently went on to have at least one more menstrual period (P < 0.05). FSH was negatively correlated with E2 (r = -0.30) and INH (r = -0.39), whereas INH was positively correlated with E2 (r = 0.45). We conclude that an increase in serum FSH and decreases in E2 and INH are the major endocrine changes associated cross-sectionally with the menopausal transition. |
| Databáze: | OpenAIRE |
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