Evaluation of a urinary multi-parameter biomarker set for oxidative stress in children, adolescents and young adults

Autor:	Hirokazu Tsukahara, Mitsufumi Mayumi, Satoshi Tamura, Hisako Kawakami, Masayuki Maeda, Masaki Ueno, Kyouichi Sekine
Rok vydání:	2006
Předmět:	Adult Glycation End Products Advanced Male medicine.medical_specialty Adolescent Urinary system Oxidative phosphorylation medicine.disease_cause Arginine Nitric Oxide Biochemistry Nitric oxide chemistry.chemical_compound Internal medicine medicine Humans Pentosidine Acrolein Child Nitrites chemistry.chemical_classification Reactive oxygen species Nitrates business.industry Lysine 8-Hydroxy-2'-deoxyguanosine Deoxyguanosine Infant General Medicine Oxidative Stress Endocrinology chemistry 8-Hydroxy-2'-Deoxyguanosine Child Preschool Biomarker (medicine) Female business Reactive Oxygen Species Oxidative stress Biomarkers
Zdroj:	Free radical research. 40(11)
ISSN:	1071-5762
Popis:	The involvement of reactive oxygen species (ROS) and oxidative stress in pediatric diseases is an important concern, but oxidative stress status in healthy young subjects and appropriate methods for its measurement remain unclear. This study evaluated a comprehensive set of urinary biomarkers for oxidative stress in healthy children, adolescents and young adults. Results show that urinary excretion of acrolein-lysine, 8-hydroxy-2'-deoxyguanosine (8-OHdG), nitrite/nitrate and pentosidine were highest in the youngest subjects and decreased to constant levels by early adolescence. Urinary acrolein-lysine, 8-OHdG, nitrite/nitrate and pentosidine showed significant inverse correlations with age, but pyrraline did not change significantly with age. No significant differences in biomarkers were apparent between males and females. Younger subjects grow rapidly and sustain immune activation, and are probably exposed to high concentrations of ROS and nitric oxide. Consequently, they are more vulnerable to oxidation of lipids, proteins, DNA and carbohydrates. Normal reported values in this study are a basis for future studies of disease mechanisms involving oxidative stress and for future trials using antioxidant therapies for oxidative stress-related diseases in the pediatric field.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9285c34180b5717f6d9fc22d9d2e319f https://pubmed.ncbi.nlm.nih.gov/17050173 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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