Quality of life and quality-adjusted survival (Q-TWiST) in patients receiving dose-intensive or standard dose chemotherapy for high-risk primary breast cancer
| Autor: | Richard D. Gelber, Russell L. Basser, Stefan Aebi, Juerg Bernhard, Winnie Yeo, David Zahrieh, Giovanni Martinelli, Beat Thürlimann, Alan S. Coates, M.A. Colleoni, C. Hürny, J. J. Zhang, Karen N. Price, Michael D. Green, A. Goldhirsch, M. Castiglione-Gertsch, John F. Forbes |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Oncology
Adult Cancer Research medicine.medical_specialty Cyclophosphamide Anthracycline quality-adjusted survival medicine.medical_treatment Breast Neoplasms adaptation Filgrastim Breast cancer breast cancer Risk Factors Internal medicine Clinical Studies Antineoplastic Combined Chemotherapy Protocols medicine Humans Longitudinal Studies Survival rate Epirubicin Chemotherapy Dose-Response Relationship Drug business.industry Standard treatment medicine.disease Surgery adjuvant chemotherapy Survival Rate quality of life Chemotherapy Adjuvant Doxorubicin Female Quality-Adjusted Life Years Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Quality of life (QL) is an important consideration when comparing adjuvant therapies for early breast cancer, especially if they differ substantially in toxicity. We evaluated QL and Q-TWiST among patients randomised to adjuvant dose-intensive epirubicin and cyclophosphamide administered with filgrastim and progenitor cell support (DI-EC) or standard-dose anthracycline-based chemotherapy (SD-CT). We estimated the duration of chemotherapy toxicity (TOX), time without disease symptoms and toxicity (TWiST), and time following relapse (REL). Patients scored QL indicators. Mean durations for the three transition times were weighted with patient reported utilities to obtain mean Q-TWiST. Patients receiving DI-EC reported worse QL during TOX, especially treatment burden (month 3: P |
| Databáze: | OpenAIRE |
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