Gestational risk factors and childhood cancers: A cohort study in Taiwan
| Autor: | Pei-Chen Lee, Chung Yi Li, Beate Ritz, Julia E. Heck, Hsin Yun Tsai, Chia Kai Wu, Onyebuchi A. Arah |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Birth weight Taiwan Gestational Age Fetal Development 03 medical and health sciences 0302 clinical medicine demographics Risk Factors Neoplasms Very Preterm Birth Medicine Birth Weight Humans Child Demography business.industry Obstetrics Hazard ratio Infant Newborn Gestational age birth weight Infant Pediatric cancer gestational factors pediatric cancer Low birth weight Parity Oncology 030220 oncology & carcinogenesis Child Preschool Cohort Premature Birth Female medicine.symptom business fetal growth Cohort study |
| Zdroj: | Heck, J E, Lee, P C, Wu, C K, Tsai, H Y, Ritz, B, Arah, O A & Li, C Y 2020, ' Gestational risk factors and childhood cancers : A cohort study in Taiwan ', International Journal of Cancer, vol. 147, no. 5, pp. 1343-1353 . https://doi.org/10.1002/ijc.32905 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.32905 |
| Popis: | Gestational risk factors such as birth weight, gestational age and parity have been repeatedly found to be related to pediatric cancers, but few reports have emerged from Asian countries. Here we report on demographic and gestational factors in a Taiwanese cohort. Our study included all children born in Taiwan 2004–2014 for whom there was a birth record (n = 2,079,037), of which 1900 children had been diagnosed with cancer prior to age 12. We conducted multivariable hazard regression to examine associations between demographic and gestational factors with cancer. Greater parity (family with 2+ older children) was related to acute myeloid leukemia [Hazard ratio (HR) = 2.15, 95% confidence interval (CI): 1.31, 3.55), central nervous system tumors (HR = 1.67, CI: 1.13, 2.48) and neuroblastoma (HR = 1.67, CI: 1.07, 2.63). Hepatoblastoma cases had a higher risk of low birth weight ( |
| Databáze: | OpenAIRE |
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