Carboxyhemoglobinemia, polycythemia, cardiomegaly, and cardiovascular function in the anesthetized rat
| Autor: | Michael S. Baylerian, David G. Penney |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Physiology Cardiac index Cardiomyopathy Hemodynamics Cardiomegaly Polycythemia chemistry.chemical_compound Carbon Monoxide Poisoning Physiology (medical) Heart rate medicine Animals Anesthesia Cardiac Output Pharmacology business.industry Body Weight Stroke Volume General Medicine Organ Size medicine.disease Rats medicine.anatomical_structure Blood pressure chemistry Carboxyhemoglobin Ventricle Circulatory system business |
| Zdroj: | Canadian journal of physiology and pharmacology. 65(11) |
| ISSN: | 0008-4212 |
| Popis: | The effects of carbon monoxide (CO), polycythemia (PC), and cardiomegaly (CM) on cardiovascular function were investigated in adult rats in which the latter two conditions were induced by 500 ppm CO inhalation for 5–6 weeks. Using an anesthetized open-chest preparation, these rats were compared with normal rats. With CO + PC + CM present, resting cardiac index, stroke index, stroke work, and minute work were elevated (heart rate also in the conscious state), while left ventricle end-diastolic pressure (LVDP) was normal. With PC + CM after CO washout, cardiac index and stroke index returned to normal at normal LVDP. Minute work, peripheral resistance, heart rate, and blood pressure, however, remained above normal. With CM alone, minute work, +dP/dtmax, +dF/dtmax, peripheral resistance, blood pressure, and LVDP declined from the condition with PC + CM. Although most cardiovascular parameters increased in the three conditions above with acutely increased LVDP, only with CM alone was performance augmentation normal. The results (i) reveal several characteristics of the hemodynamic response to chronic carboxyhemoglobinemia, (ii) suggest that the transient hypertension attending CO elimination in the presence of PC results from rapid reversal of peripheral vasodilatation, (iii) demonstrate decreased cardiac functional reserve with CO and (or) polycythemia upon preload challenge, and (iv) provide evidence for the benign nature of CO-induced cardiomegaly alone, on heart function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|