A systematic literature review identifying associations between outcomes and quality of life (QoL) or healthcare resource utilization (HCRU) in schizophrenia
| Autor: | Nicola Germain, Anna Jakubowska, Clément François, Elin Löf, James Weatherall, Steven Kymes |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
MEDLINE Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Quality of life Recurrence Surveys and Questionnaires Health care medicine Humans business.industry 030503 health policy & services Health Policy Patient Acceptance of Health Care medicine.disease Systematic review Treatment Outcome Schizophrenia 030220 oncology & carcinogenesis Family medicine Inclusion and exclusion criteria Chronic Disease Quality of Life Health Resources 0305 other medical science business Resource utilization Antipsychotic Agents |
| Zdroj: | Journal of medical economics. 22(5) |
| ISSN: | 1941-837X |
| Popis: | There have been no systematic literature reviews (SLRs) evaluating the identified association between outcomes (e.g. clinical, functional, adherence, societal burden) and Quality-of-Life (QoL) or Healthcare Resource Utilization (HCRU) in schizophrenia. The objective of this study was to conduct a SLR of published data on the relationship between outcomes and QoL or HCRU.Electronic searches were conducted in Embase and Medline, for articles which reported on the association between outcomes and QoL or HCRU. Inclusion and exclusion criteria were applied to identify the most relevant articles and studies and extract their data. A summary table was developed to illustrate the strength of associations, based on p-values and correlations.One thousand and two abstracts were retrieved; five duplicates were excluded; 997 abstracts were screened and 95 references were retained for full-text screening. Thrirty-one references were included in the review. The most commonly used questionnaire, which also demonstrated the strongest associations (defined as a p 0.0001 and/or correlation ±0.70), was the Positive and Negative Syndrome Scale (PANSS) associated with HCRU and QoL (the SF-36, the Schizophrenia Quality-of-Life questionnaire [S-QOL-18], the Quality-of-Life Scale [QLS]). Other robust correlations included the Clinical Global Impression-Severity (CGI-S) with QoL (EQ5D), relapse with HCRU, and remission with QoL (EQ5D). Lastly, functioning (Work Rehabilitation Questionnaire [WORQ] and Personal and Social Performance Scale [PSP]) was found to be associated to QoL (QLS and Subjective Well-being under Neuroleptics Questionnaire [SWN]).This study included data from an 11-year period, and other instruments less frequently used may be further investigated.The evidence suggests that the PANSS is the clinical outcome that currently provides the most frequent and systematic associations with HCRU and QoL endpoints in schizophrenia. |
| Databáze: | OpenAIRE |
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