Analgesic, anti-inflammatory and anti-arthritic properties of aqueous and methanolic stem bark extracts from Nauclea pobeguinii (Rubiacee) in rats
| Autor: | Nana Yousseu William, Ateufack Gilbert, Mbankou Ngassam Sorelle, Tsafack Eric Gonzal, Wego Kamgaing Marius Tresor, Mbiantcha Marius, Bomba Tatsinkou Francis Desire, Djuichou Nguemnang Stephanie Flore |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Nauclea medicine.drug_class Analgesic Anti-Inflammatory Agents Arthritis Rubiaceae medicine.disease_cause 01 natural sciences Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Diclofenac Animals Edema Humans Medicine Rats Wistar Inflammation Analgesics Plant Stems biology Traditional medicine Plant Extracts business.industry biology.organism_classification Malondialdehyde medicine.disease Acute Pain Rats 0104 chemical sciences 010404 medicinal & biomolecular chemistry Complementary and alternative medicine chemistry Catalase 030220 oncology & carcinogenesis Plant Bark biology.protein Female business Oxidative stress Phytotherapy medicine.drug |
| Zdroj: | Journal of Complementary and Integrative Medicine. 15 |
| ISSN: | 1553-3840 2194-6329 |
| Popis: | Background Nauclea pobeguinii is a plant species found in the centre region of Cameroon. The stem bark of this plant is traditionally used to ease pain and cure inflammation. Method This study was undertaken to evaluate the effects of doses 150 and 300 mg/kg of the aqueous and methanolic stem bark extracts from Nauclea pobeguinii on acute pain, acute and chronic inflammation induced by formalin and arthritis induced by zymosan A in rats. Oxidative stress parameters such as catalase, malondialdehyde and nitric oxide were measured in rats subjected to chronic inflammation. The standard used was diclofenac at 5 mg/kg. Results Aqueous extract as well as methanolic extract of Nauclea pobeguinii led to a significant reduction in the second phase of formalin induced pain with 54.22 and 48.02% of inhibition percentage, respectively. The formalin-induced inflammatory oedema was reduced by both extracts, and this effect remains significant until the tenth day of treatment. Equally, extracts significantly increased the catalase activity and inhibited the production of malondialdehyde (MDA) in serum, brain and spinal cord and NO reduction only in serum. Both extracts significantly reduced the articular oedema induced by zymosan A for 6 h and for 5 days. Furthermore, the histological study of the articulations shows a non-altered synovial membrane and a small cartilage in all treated animals versus negative control group. Conclusions From these results, it can be concluded that pain, inflammation and arthritic healing activities of both stem bark extracts were expressed in rats and could conciliate the use of this vegetable by traditional African healers. |
| Databáze: | OpenAIRE |
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