Isolation, characterization and biological activity of betulinic acid and ursolic acid from Vitex negundo L
Autor: | David G L Krupadanam, Reddy Vudem Dashavantha, Rao D Manohar, C Chandramu |
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Rok vydání: | 2003 |
Předmět: |
Insecticides
Vitex negundo Stereochemistry Microbial Sensitivity Tests Moths Biology Vitex chemistry.chemical_compound Ursolic acid Triterpene Betulinic acid Escherichia coli Animals Humans Betulinic Acid Antibacterial agent Pharmacology chemistry.chemical_classification Dose-Response Relationship Drug Traditional medicine Plant Extracts Biological activity Feeding Behavior biology.organism_classification Triterpenes Anti-Bacterial Agents Plant Leaves chemistry Larva Pentacyclic Triterpenes Antibacterial activity Bacillus subtilis Phytotherapy |
Zdroj: | Phytotherapy Research. 17:129-134 |
ISSN: | 1099-1573 0951-418X |
Popis: | Two pentacyclic triterpenoids, betulinic acid (3beta-hydroxylup-20-(29)-en-28-oic acid) (3), and ursolic acid (2beta-hydroxyurs-12-en-28-oic acid) (4), were isolated for the first time from leaves of Vitex negundo L. along with three other compounds; an aliphatic alcohol n-hentriacontanol (1), beta-sitosterol (2) and p-hydroxybenzoic acid (5). Their antifeedant activity against the larvae of an agricultural pest, the castor semilooper (Achoea janata), in a no-choice laboratory assay and their antibacterial activity against Bacillus subtilis and Escherichia coli, by the paper disc method, were tested. Ursolic acid (4) showed more effective antifeedant activity than the betulinic acid (3). However, both these compounds have shown a very mild antibacterial activity. The other three compounds; n-hentriacontanol (1), beta-sitosterol (2) and p-hydroxybenzoic acid (5) have shown a little antifeedant activity against the larvae and did not show any antibacterial activity. |
Databáze: | OpenAIRE |
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