Serum Biomarkers of Immune Activation and Subsequent Risk of Non-Hodgkin B-Cell Lymphoma among HIV-Infected Women
| Autor: | Gypsyamber D'Souza, Kathryn Anastos, Mardge H. Cohen, Otoniel Martinez-Maza, Elizabeth C. Breen, Alexandra M. Levine, Nancy A. Hessol, Sylvia Silver, Shehnaz K. Hussain, Deborah Gustafson |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Oncology medicine.medical_specialty Lymphoma B-Cell Epidemiology HIV Infections Lymphocyte Activation Article immune system diseases hemic and lymphatic diseases Internal medicine Biomarkers Tumor Humans Medicine Longitudinal Studies Prospective Studies Risk factor B-cell lymphoma Prospective cohort study Lymphoma AIDS-Related B-Lymphocytes business.industry Case-control study Odds ratio Middle Aged medicine.disease Confidence interval Lymphoma Case-Control Studies Immunology Biomarker (medicine) Female business |
| Zdroj: | Cancer Epidemiology, Biomarkers & Prevention. 22:2084-2093 |
| ISSN: | 1538-7755 1055-9965 |
| DOI: | 10.1158/1055-9965.epi-13-0614 |
| Popis: | Background: There is increasing evidence that chronic immune activation predisposes to non-Hodgkin lymphoma (NHL). Whether this association exists among women representative of the current HIV epidemic in the United States who are at high risk of HIV-associated NHL (AIDS-NHL), remains to be determined. Methods: We conducted a nested case–control study within the Women's Interagency HIV Study with longitudinally collected risk factor data and sera. Cases were HIV-infected women with stored sera collected at three time-windows 3 to 5 years, 1 to 3 years, and 0 to 1 year before AIDS-NHL diagnosis (n = 22). Three to six HIV-infected controls, without AIDS-NHL, were matched to each case on age, race, CD4+ T-cell count, and study follow-up time (n = 78). ORs and 95% confidence intervals (CI) for the association between one unit increase in log-transformed biomarker levels and AIDS-NHL were computed using random effect multivariate logistic regression models. Results: Elevated levels of sCD27 (OR = 7.21; 95% CI, 2.62–19.88), sCD30 (OR = 2.64; 95% CI, 1.24–5.64), and CXCL13 (OR = 2.56; 95% CI, 1.32–4.96) were associated with subsequent diagnosis of AIDS-NHL overall. Elevated sCD23 was associated with a two to three-fold increased risk of AIDS-NHL in certain subgroups, whereas elevated interleukin 6 was associated with a two-fold increased risk in the 0 to 1 year time-window, only. Conclusions: These findings support the hypothesis that chronic B-cell activation contributes to the development of AIDS-NHL in women. Impact: Soluble CD23 (sCD23), sCD27, sCD30, and CXCL13 may serve as biomarkers for AIDS-NHL. Cancer Epidemiol Biomarkers Prev; 22(11); 2084–93. ©2013 AACR. |
| Databáze: | OpenAIRE |
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