Chromosome region 8p11-p21: refined mapping and molecular alterations in breast cancer

Autor: Robert Zeillinger, Marie Josèphe Pébusque, Dirk C. J. G. van Alewijk, Anne Lise Børresen-Dale, Florence Allione, Alexandra Imbert, Jan Trapman, Cornel Popovici, Rosette Lidereau, Daniel Birnbaum, José Adélaïde, Jeanine Geneix, Max Chaffanet
Přispěvatelé: Pathology, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 1998
Předmět:
Zdroj: Genes Chromosomes & Cancer, 22, 186-199. Wiley-Liss Inc.
Genes, Chromosomes & Cancer
Genes, Chromosomes & Cancer, 1998, 22 (3), pp.186-199. ⟨10.1002/(SICI)1098-2264(199807)22:33.0.CO;2-S⟩
ISSN: 1045-2257
1098-2264
DOI: 10.1002/(SICI)1098-2264(199807)22:33.0.CO;2-S⟩
Popis: International audience; Several genes, most of them unknown, of the short arm of chromosome 8 are involved in malignant diseases. Numerous studies have implicated a portion of the 8p11-p21 region as the location of one or more tumor suppressor genes involved in a variety of human cancers, including breast cancer. We and others have reported linkage analyses suggesting the presence of a putative breast cancer susceptibility gene. Furthermore, several oncogenes of the 8p11-p12 region are involved in reciprocal translocations in myeloproliferative and myelodysplastic disorders and in amplification in breast cancer. To facilitate the analysis of the 8p11-p21 region and the cloning of candidate oncogenes and tumor suppressor genes, a high-resolution physical and transcriptional map was established with 39 yeast artificial chromosomes and 94 markers, including so-called sequence-tagged sites and expressed sequence-tagged sites derived from either known genes or expressed sequence tags corresponding to unidentified transcripts. In addition, four novel transcripts were identified and localized precisely within the map. This transcription map provides a detailed description of gene order for the 8p11-p21 region and will be helpful in the identification of candidate genes for diseases. From this basis, we refined the mapping of two types of molecular alterations that occur at 8p11-p21 in sporadic breast cancers, i.e., amplification and deletion.
Databáze: OpenAIRE
Externí odkaz: