Long-term Outcome of Children Born to Women with Autoimmune Rheumatic Diseases: A Multicentre, Nationwide Study on 299 Randomly Selected Individuals
| Autor: | Carolina Benigno, Elena Bartoloni, Roberto Caporali, Maria Favaro, Chiara Tani, Armin Maier, Angela Ceribelli, M Vadacca, Carlo Salvarani, M. Meroni, Elisa Visalli, Amelia Ruffatti, Alessandra Bortoluzzi, S. Peccatori, Pier Luigi Meroni, Francesco Paolo Cantatore, Salvatore D'Angelo, Giuseppe Paolazzi, Eleonora Valentini, Gian Domenico Sebastiani, Marta Mosca, Elena Generali, Elena Baldissera, Angela Tincani, Giulia Pazzola, Véronique Ramoni, Melissa Padovan, L Zuliani, M Rodrigues, Francesca Serale, Maddalena Larosa, Cecilia Beatrice Chighizola, Rossella Reggia, Valentina Picerno, Rosario Foti, Maria Grazia Lazzaroni, Addolorata Corrado, Francesca Bellisai, Nazzarena Malavolta, Francesca Dall'Ara, Armando Gabrielli, Roberto Gerli, Cecilia Nalli, Elena De Stefani, Giorgio Pettiti, Luigi Sinigaglia, C Carini, Laura Andreoli, Maria Gerosa, Carlomaurizio Montecucco, Fabio Basta, Paola Conigliaro, Roberto Perricone, Maurizio Cutolo, I. Prevete, Corrado Campochiaro, Andrea Doria, Carlo Selmi, N Romeo, M Trevisani, Guido Valesini, Colomba Fischetti, E Vivaldelli |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Male Pediatrics medicine.medical_specialty Offspring Disease Autoimmune Diseases NO Cohort Studies 03 medical and health sciences 0302 clinical medicine Rheumatic diseases Pregnancy Reproductive issues medicine Immunology and Allergy Humans Child Prenatal exposure Autoantibodies 030203 arthritis & rheumatology business.industry Neurodevelopmental disorders General Medicine Maternal autoantibodies Counselling Reproductive Issues 030104 developmental biology Increased risk Antirheumatic Agents Childbearing age Cohort Female business |
| Popis: | The concern about the offspring’s health is one of the reasons for a reduced family size of women with rheumatic diseases (RD). Increased risk of autoimmune diseases (AD) and neurodevelopmental disorders (ND) has been reported in children born to patients with RD. Within a nationwide survey about reproductive issues of women with RD, we aimed at exploring the long-term outcome of their children. By surveying 398 patients who received their diagnosis of RD during childbearing age (before the age of 45), information about the offspring were obtained from 230 women who declared to have had children. A total of 148 (64.3%) patients were affected by connective tissue diseases (CTD) and 82 (35.7%) by chronic arthritis. Data on 299 children (156 males, 52.1%; mean age at the time of interview 17.1 ± 9.7 years) were collected. Twelve children (4.0%), who were born to patients with CTD in 75% of the cases, were affected by AD (8 cases of celiac disease). Eleven children had a certified diagnosis of ND (3.6%; 6 cases of learning disabilities); 9 of them were born to mothers with CTD (5 after maternal diagnosis). No association was found between ND and prenatal exposure to either maternal autoantibodies or anti-rheumatic drugs. Absolute numbers of offspring affected by AD and ND were low in a multicentre cohort of Italian women with RD. This information can be helpful for the counselling about reproductive issues, as the health outcomes of the offspring might not be an issue which discourage women with RD from having children. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|