In vitro studies on chemoprotective effect of purnark against benzo(a)pyrene-induced chromosomal damage in human lymphocytes
| Autor: | S V Bhide, S D Ghaisas |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Curcumin Adolescent DNA damage Sister chromatid exchange Biology medicine.disease_cause complex mixtures chemistry.chemical_compound Botany Benzo(a)pyrene medicine Anticarcinogenic Agents Chromosomes Human Humans Lymphocytes Carcinogen Micronucleus Tests Biological activity Cell Biology General Medicine Molecular biology chemistry Micronucleus test Chemoprotective Female Sister Chromatid Exchange Genotoxicity DNA Damage |
| Zdroj: | Cell Biology International. 18:21-28 |
| ISSN: | 1065-6995 |
| DOI: | 10.1006/cbir.1994.1003 |
| Popis: | Human lymphocytes were used as an assay system to test chemopreventive activity of natural products. Purnark, a mixture of extracts of turmeric, betel leaf and catechu, was tested for its chemoprotective activity against BP induced DNA damage. Sister chromatid exchange and micronuclei were used as markers to assess the protective activity of Purnark. Purnark gave 50-60% protection against BP induced SCEs and micronuclei. Purnark at 100 micrograms dose did not show any genotoxicity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text