Prevalence of Fetal Alcohol Spectrum Disorders in 4 US Communities
| Autor: | Melanie A. Manning, David Buckley, Julie M. Hasken, Luther K. Robinson, Haruna S. Feldman, Margaret P. Adam, Keith K. Vaux, Gordon Honerkamp-Smith, Amy J. Elliott, Michael E. Charness, Claire D. Coles, Ronghui Xu, Daniel E. Falk, David Kopald, Kenneth R. Warren, Wendy O. Kalberg, Tamison Jewett, Kenneth L. Jones, Judith A. Arroyo, Jennifer A. Zellner, Edward P. Riley, Julie A. Kable, Christina D. Chambers, Dale Hereld, Omar A. Abdul-Rahman, Natacha Akshoomoff, Howard Taras, Philip A. May, H. Eugene Hoyme |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cross-sectional study Population Fetal alcohol syndrome Mothers 010501 environmental sciences 01 natural sciences Sampling Studies 03 medical and health sciences Fetal alcohol 0302 clinical medicine Neurodevelopmental disorder Pregnancy medicine Prevalence Humans 030212 general & internal medicine education Child Original Investigation 0105 earth and related environmental sciences education.field_of_study business.industry Obstetrics and Gynecology Mean age General Medicine medicine.disease Alcohol consumption during pregnancy United States Cross-Sectional Studies Socioeconomic Factors Fetal Alcohol Spectrum Disorders Prenatal alcohol exposure Fetal Alcohol Spectrum Disorder Child Preschool Female business 030217 neurology & neurosurgery Demography |
| Zdroj: | JAMA. 319(5) |
| ISSN: | 1538-3598 |
| Popis: | Importance Fetal alcohol spectrum disorders are costly, life-long disabilities. Older data suggested the prevalence of the disorder in the United States was 10 per 1000 children; however, there are few current estimates based on larger, diverse US population samples. Objective To estimate the prevalence of fetal alcohol spectrum disorders, including fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder, in 4 regions of the United States. Design, Setting, and Participants Active case ascertainment methods using a cross-sectional design were used to assess children for fetal alcohol spectrum disorders between 2010 and 2016. Children were systematically assessed in the 4 domains that contribute to the fetal alcohol spectrum disorder continuum: dysmorphic features, physical growth, neurobehavioral development, and prenatal alcohol exposure. The settings were 4 communities in the Rocky Mountain, Midwestern, Southeastern, and Pacific Southwestern regions of the United States. First-grade children and their parents or guardians were enrolled. Exposures Alcohol consumption during pregnancy. Main Outcomes and Measures Prevalence of fetal alcohol spectrum disorders in the 4 communities was the main outcome. Conservative estimates for the prevalence of the disorder and 95% CIs were calculated using the eligible first-grade population as the denominator. Weighted prevalences and 95% CIs were also estimated, accounting for the sampling schemes and using data restricted to children who received a full evaluation. Results A total of 6639 children were selected for participation from a population of 13 146 first-graders (boys, 51.9%; mean age, 6.7 years [SD, 0.41] and white maternal race, 79.3%). A total of 222 cases of fetal alcohol spectrum disorders were identified. The conservative prevalence estimates for fetal alcohol spectrum disorders ranged from 11.3 (95% CI, 7.8-15.8) to 50.0 (95% CI, 39.9-61.7) per 1000 children. The weighted prevalence estimates for fetal alcohol spectrum disorders ranged from 31.1 (95% CI, 16.1-54.0) to 98.5 (95% CI, 57.5-139.5) per 1000 children. Conclusions and Relevance Estimated prevalence of fetal alcohol spectrum disorders among first-graders in 4 US communities ranged from 1.1% to 5.0% using a conservative approach. These findings may represent more accurate US prevalence estimates than previous studies but may not be generalizable to all communities. |
| Databáze: | OpenAIRE |
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