Evolution of Chordate Hox Gene Clustersa
| Autor: | Frank H. Ruddle, Chris T. Amemiya, Cooduvalli S. Shashikant, Christina Ledje, Günter P. Wagner, Chang Bae Kim, Janet L. Carr |
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| Rok vydání: | 1999 |
| Předmět: |
DNA
Complementary Semiconservative replication Molecular Sequence Data Chordate Genome General Biochemistry Genetics and Molecular Biology Evolution Molecular Mice History and Philosophy of Science biology.animal Gene duplication Animals Humans Enhancer Hox gene Zebrafish Homeodomain Proteins Genetics Base Sequence biology General Neuroscience Fishes Whales Vertebrate biology.organism_classification Body plan Evolutionary biology Multigene Family Chickens |
| Zdroj: | Annals of the New York Academy of Sciences. 870:238-248 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.1999.tb08884.x |
| Popis: | In this article, we consider the role of the Hox genes in chordate and vertebrate evolution from the viewpoints of molecular and developmental evolution. Models of Hox cluster duplication are considered with emphasis on a threefold duplication model. We also show that cluster duplication is consistent with a semiconservative model of duplication, where following duplication, one daughter cluster remains unmodified, while the other diverges and assumes a new architecture and presumably new functions. Evidence is reviewed, suggesting that Hox gene enhancers have played an important role in body plan evolution. Finally, we contrast the invertebrates and vertebrates in terms of genome and Hox cluster duplication which are present in the latter, but not the former. We question whether gene duplication has been important in vertebrates for the introduction of novel features such as limbs, a urogenital system, and specialized neuromuscular interactions. |
| Databáze: | OpenAIRE |
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