On Group Sequential Designs Comparing Two Binomial Proportions
| Autor: | James L. Kepner |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Statistics and Probability Models Statistical Early stopping Binomial (polynomial) Fortran Statistical power Exact test Clinical Trials Phase II as Topic Clinical Trials Phase III as Topic Research Design Sample size determination Search algorithm Sample Size Statistics Humans Pharmacology (medical) computer Mathematics Statistical hypothesis testing computer.programming_language |
| Zdroj: | Journal of Biopharmaceutical Statistics. 20:145-159 |
| ISSN: | 1520-5711 1054-3406 |
| Popis: | Discussed is the problem of sample size determination for one- and two-stage hypothesis tests comparing two binomial proportions using two independent random samples. A FORTRAN compiled search algorithm identifies exact group sequential designs that allow early stopping only for futility or only for efficacy or for either futility or efficacy. The resulting designs yield a substantial savings in terms of total sample size in many practical cases, are seen to satisfy a number of desirable properties, and are compared to other exact one- and two-stage designs and to designs derived based upon asymptotic normal theory methods. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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