Nanomaterials Designed for Antiviral Drug Delivery Transport across Biological Barriers
| Autor: | Doru Botezat, Ioannis Gardikiotis, Elena Rezus, Laura Mihaela Trandafir, Gianina Dodi, Bogdan-Ionel Tamba, Florina-Daniela Cojocaru, Cristina-Mariana Uritu, Cosmin Teodor Mihai, Ciprian Rezus |
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| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
biological barriers medicine.drug_class business.industry lcsh:RS1-441 Pharmaceutical Science Review 02 engineering and technology Increased drug resistance 021001 nanoscience & nanotechnology Bioinformatics lcsh:Pharmacy and materia medica Clinical Practice 03 medical and health sciences antivirals In vivo drug delivery Drug delivery medicine Antiviral drug 0210 nano-technology business nanomaterials 030304 developmental biology |
| Zdroj: | Pharmaceutics, Vol 12, Iss 2, p 171 (2020) Pharmaceutics |
| ISSN: | 1999-4923 |
| Popis: | Viral infections are a major global health problem, representing a significant cause of mortality with an unfavorable continuously amplified socio-economic impact. The increased drug resistance and constant viral replication have been the trigger for important studies regarding the use of nanotechnology in antiviral therapies. Nanomaterials offer unique physico-chemical properties that have linked benefits for drug delivery as ideal tools for viral treatment. Currently, different types of nanomaterials namely nanoparticles, liposomes, nanospheres, nanogels, nanosuspensions and nanoemulsions were studied either in vitro or in vivo for drug delivery of antiviral agents with prospects to be translated in clinical practice. This review highlights the drug delivery nanosystems incorporating the major antiviral classes and their transport across specific barriers at cellular and intracellular level. Important reflections on nanomedicines currently approved or undergoing investigations for the treatment of viral infections are also discussed. Finally, the authors present an overview on the requirements for the design of antiviral nanotherapeutics. |
| Databáze: | OpenAIRE |
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