Further studies on the site and mechanism of action of s-(1,2 dichlorovinyl)-l-cysteine and s-(1,2 dichlorovinyl)-3-mercaptopropionic acid in rat liver
| Autor: | Michael D. Stonard |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Vinyl Compounds
3-Mercaptopropionic Acid Mitochondria Liver In Vitro Techniques Biochemistry Ammonia chemistry.chemical_compound Cytosol medicine Animals Cysteine Sulfhydryl Compounds Pyruvates Pharmacology Proteins Metabolism Lipids Rats Kinetics Glutathione Reductase Liver Mechanism of action chemistry Rat liver Lactates Pyruvic acid Propionates medicine.symptom Oxidoreductases |
| Zdroj: | Biochemical Pharmacology. 22:1329-1335 |
| ISSN: | 0006-2952 |
| DOI: | 10.1016/0006-2952(73)90307-9 |
| Popis: | DCVC, but not DCVMP, inhibits lipoyl dehydrogenase activity of isolated rat liver mitochondria and glutathione reductase activity of rat liver cytosol. DCVC can be degraded to pyruvic acid and ammonia by the cytosolic fraction of rat liver. Metabolism of DCVC by the cytosolic fraction appears necessary for inhibition of glutathione reductase activity. |
| Databáze: | OpenAIRE |
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