Changes in blood glucose concentration in the carotid body-sinus modify brain glucose retention
| Autor: | Elena Roces de Álvarez-Buylla, Alvarez-Buylla R |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Chemoreceptor medicine.medical_treatment Central nervous system Oxygen Consumption In vivo Internal medicine medicine Animals Insulin Rats Wistar Molecular Biology Brain Chemistry Carotid Body Cyanides business.industry General Neuroscience Chemoreceptor Cells Carotid sinus Rats Endocrinology medicine.anatomical_structure Glucose Carotid body Neurology (clinical) business Perfusion Developmental Biology |
| Zdroj: | Brain research. 654(1) |
| ISSN: | 0006-8993 |
| Popis: | To test whether blood glucose concentration in the carotid body-sinus may influence the amount of glucose retained by the brain, the isolated carotid sinus was perfused with glucose-rich blood or glucose-poor blood from a second animal. The circulation of the right carotid body-sinus was temporarily isolated in rat A, and perfused with blood coming from rat B. Blood glucose in rat B was modified by injections of glucose or insulin. Changes in glucose retention by the brain were measured in rat A. When the isolated carotid body-sinus in rat A was perfused with hyperglycemic blood (16.7 mM), brain glucose retention in rat A decreased significantly from 0.14 +/- 0.02 mumol/g/min (t = 0) to 0.08 +/- 0.01 mumol/g/min at 4 min after the beginning of perfusion. In contrast, the perfusion of the isolated carotid body-sinus of rat A with hypoglycemic blood (2.7 mM) from rat B, had the opposite effect. Brain glucose retention in rat A increased (0.23 +/- 0.03 mumol/g/min) at t = 4 min in comparison to control values (0.13 +/- 0.01 mumol/g/min). Chemoreceptor activity was also manipulated by the injection of cyanide (NaCN) in rat B, under these conditions, brain glucose retention in rat A increased from 0.13 +/- 0.01 mumol/g/min to 0.28 +/- 0.03 mumol/g/min between 4 to 8 min after the beginning of perfusion. These results indicate that chemosensory activity within the carotid body-sinus, superfused in vivo with different glucose concentrations, modify glucose retention by the brain. |
| Databáze: | OpenAIRE |
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