A prospective analysis of factors associated with decreased physical activity in patients with cirrhosis undergoing transplant evaluation

Autor:	Timothy L. Uhl, Michael F. Daily, Achuthan Sourianarayanane, Sooyeon Kim, Malay B. Shah, Trushar Patel, Benjamin Thomas Barnes, Roberto Gedaly, Karyn A. Esser, Roberto Galuppo, Abhishek Ravinuthala, Anthony Zanni, Valery Vilchez, Anna C. Dela Cruz, Erin Maynard
Rok vydání:	2015
Předmět:	Adult Liver Cirrhosis Male medicine.medical_specialty Alcoholic liver disease Cirrhosis medicine.medical_treatment Liver transplantation Motor Activity Gastroenterology Severity of Illness Index Article End Stage Liver Disease Grip strength Liver disease Risk Factors Internal medicine Hand strength Medicine Humans Prospective Studies Aged Transplantation Hand Strength business.industry Hepatitis C Middle Aged medicine.disease Prognosis Surgery Liver Transplantation Case-Control Studies Female business Follow-Up Studies
Zdroj:	Clinical transplantation. 29(11)
ISSN:	1399-0012
Popis:	Background Physical activity (PA) has been associated with improved recovery time after transplantation. Handgrip strength has been related to post-transplant outcomes. Aim To evaluate predictors of PA and grip strength in patients with cirrhosis undergoing liver transplant evaluation. Methods Single-center, prospective analysis. Results One hundred patients were evaluated (54% male, mean age 53 ± 9). Common etiologies of liver disease were non-alcoholic steatohepatitis (27%), hepatitis C (22%) and alcoholic liver disease (21%). Mean model of end-stage liver disease (MELD) score was 13.5. Forty-one percent had a history of smoking. Ninety-three patients completed the International Physical Activity Questionnaire (IPAQ). The median total PA score was 33 metabolic equivalent (MET)-min/wk. The mean total grip strength was 62.1 ± 22 lb. Total grip strength was found to be an independent predictor of low–moderate PA (OR 4.7, 95% CI 1.4–16.2, p = 0.038), and smoking was the only significant factor associated with reduced grip strength (OR 3.4, 95% CI 1.4–8, p = 0.005). Conclusions Patients with end-stage liver disease undergoing liver transplant evaluation have reduced total PA by IPAQ. Total grip strength was found to be a significant predictor of low–moderate PA in patients with cirrhosis. Smoking is a risk factor for reduced grip strength, an important indicator of muscle wasting in cirrhotics.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92780c8c338d9c8133f1713c99b91efc https://pubmed.ncbi.nlm.nih.gov/26263921 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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