The relationships between hypoxia-dependent markers: HIF-1alpha, EPO and EPOR in colorectal cancer
| Autor: | Maria Elzbieta Sobaniec-Lotowska, Andrzej Wincewicz, Marcin Baltaziak, Luiza Kanczuga-Koda, Monika Podbielski, Joanna Maria Lotowska, Marek Baltaziak, Urszula Sulkowska, Stanislaw Sulkowski, Mariusz Koda |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Histology Colorectal cancer Biology Pathology and Forensic Medicine Metastasis chemistry.chemical_compound Internal medicine medicine Receptors Erythropoietin Humans Lymph node Erythropoietin Aged General Medicine Middle Aged medicine.disease Hypoxia-Inducible Factor 1 alpha Subunit Cell Hypoxia Erythropoietin receptor Vascular endothelial growth factor Endocrinology medicine.anatomical_structure chemistry Tumor progression Cancer research Immunohistochemistry Female Colorectal Neoplasms medicine.drug |
| Zdroj: | Folia histochemica et cytobiologica. 51(4) |
| ISSN: | 1897-5631 |
| Popis: | Hypoxia triggers production of several cytoprotective proteins. Hypoxia-inducible factor 1alpha (HIF-1α) is a powerful stimulator of transcription of many genes, including erythropoietin (EPO) in hypoxia-affected cells. Recent data have also implicated signaling by EPO receptor (EPOR) as a new factor influencing tumor progression. The aim of the study was to detect by immunohistochemistry the presence of HIF-1α, EPO and EPOR in colorectal cancer (CRC) in reference to clinicopathological variables. We found the presence of the studied proteins in specimens of all 125 CRC patients which is suggestive of the occurrence of hypoxia in colorectal cancer tissues. The expression of HIF-1α correlated significantly with the presence of EPO and EPOR in all samples (P < 0.001, r = 0.549 and P < 0.001, r = 0.536, respectively). Significant correlations (from P < 0.024 to P < 0.001) were found in the analyses of CRC subgroups such as histopathological type tumor, tumor grade, tumor stage and patients with lymph nodes metastases. The same high significant correlations (P < 0.001) were observed in group of sex, age and tumor location. However, the values of the correlation coefficients (r) which usually ranged from 0.5 to 0.6 suggest the existence of independent or concurrent mechanism stimulating generation of these proteins in colorectal cancer. |
| Databáze: | OpenAIRE |
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