A novel screening strategy for clinically significant prostate cancer in elderly men over 75 years of age
| Autor: | Renato Naito, Tomoyuki Makino, Kazuyoshi Shigehara, Hiroshi Yaegashi, Hiroaki Iwamoto, Kouji Izumi, Suguru Kadomoto, Yoshifumi Kadono, Atsushi Mizokami |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male medicine.medical_specialty Prostate biopsy Urology Biopsy lcsh:RC870-923 elderly Sensitivity and Specificity Prostate cancer Prostate Internal medicine biopsy gleason score percent free prostate-specific antigen prostate cancer prostate-specific antigen medicine Humans Gleason score Early Detection of Cancer Aged Retrospective Studies Aged 80 and over medicine.diagnostic_test business.industry Age Factors Prostatic Neoplasms Retrospective cohort study General Medicine Rectal examination Prostate-Specific Antigen medicine.disease Percent Free Prostate-Specific Antigen lcsh:Diseases of the genitourinary system. Urology Prostate-specific antigen medicine.anatomical_structure Original Article Kallikreins Neoplasm Grading business |
| Zdroj: | Asian Journal of Andrology Asian Journal of Andrology, Vol 23, Iss 1, Pp 36-40 (2021) |
| ISSN: | 1745-7262 1008-682X |
| Popis: | A standard modality for prostate cancer detection in men 75 years and older has not been established. A simple screening method for elderly patients is needed to avoid unnecessary biopsies and to effectively diagnose prostate cancer. A retrospective study was conducted on elderly patients who had prostate biopsy at Kanazawa University Hospital (Kanazawa, Japan) between 2000 and 2017. Of the 2251 patients who underwent prostate biopsy, 254 had clinically significant prostate cancer (CSPC) with a Gleason score (GS) of ≥ 7 and 273 had a GS of 24, PSA density ≥ 0.24 ng ml−2, positive findings on digital rectal examination, and transrectal with 90.0% sensitivity and 67.4% specificity. In this study, we found that raising the PSA cutoff to 12 ng ml−1 for CSPC in elderly individuals can significantly reduce unnecessary prostate biopsies. Furthermore, CSPC could be efficiently discovered by combining the four supplementary markers in patients with a PSA level of 4–12 ng ml−1. By performing this screening for elderly men over 75 years of age, unnecessary biopsies may be reduced and CSPC may be detected efficiently. |
| Databáze: | OpenAIRE |
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