Sex-Specific Social Behavior and Amygdala Proteomic Deficits in Foxp2+/− Mutant Mice
| Autor: | Heidi Y. Matos, Li Wang, Aswini Panigrahi, David Hernandez-Pineda, Nathan A. Smith, Meredith Goodrich, Maria Jesus Herrero, Payal Banerjee, Joshua G. Corbin |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cognitive Neuroscience Neurosciences. Biological psychiatry. Neuropsychiatry Biology Amygdala social behavior medial amygdala (MeA) 03 medical and health sciences Behavioral Neuroscience proteomics 0302 clinical medicine Dopamine medicine Loss function Original Research Aggression aggression food and beverages FOXP2 medicine.disease Social relation 030104 developmental biology medicine.anatomical_structure Neuropsychology and Physiological Psychology Foxp2 Autism sex-specific differences medicine.symptom Neuroscience 030217 neurology & neurosurgery RC321-571 Social behavior medicine.drug |
| Zdroj: | Frontiers in Behavioral Neuroscience Frontiers in Behavioral Neuroscience, Vol 15 (2021) |
| ISSN: | 1662-5153 |
| DOI: | 10.3389/fnbeh.2021.706079 |
| Popis: | In humans, mutations in the transcription factor encoding gene, FOXP2, are associated with language and Autism Spectrum Disorders (ASD), the latter characterized by deficits in social interactions. However, little is known regarding the function of Foxp2 in male or female social behavior. Our previous studies in mice revealed high expression of Foxp2 within the medial subnucleus of the amygdala (MeA), a limbic brain region highly implicated in innate social behaviors such as mating, aggression, and parental care. Here, using a comprehensive panel of behavioral tests in male and female Foxp2+/– heterozygous mice, we investigated the role Foxp2 plays in MeA-linked innate social behaviors. We reveal significant deficits in olfactory processing, social interaction, mating, aggressive, and parental behaviors. Interestingly, some of these deficits are displayed in a sex-specific manner. To examine the consequences of Foxp2 loss of function specifically in the MeA, we conducted a proteomic analysis of microdissected MeA tissue. This analyses revealed putative sex differences expression of a host of proteins implicated in neuronal communication, connectivity, and dopamine signaling. Consistent with this, we discovered that MeA Foxp2-lineage cells were responsive to dopamine with differences between males and females. Thus, our findings reveal a central and sex-specific role for Foxp2 in social behavior and MeA function. |
| Databáze: | OpenAIRE |
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