Increased survival by feeding tetradecylthioacetic acid during a natural outbreak of heart and skeletal muscle inflammation in S0 Atlantic salmon, Salmo salar L
| Autor: | Magny S. Thomassen, Rolf K. Berge, Trygve Sigholt, Maike Oehme, Kjell-Arne Rørvik, Fabian Grammes, Harald Takle, Ståle Refstie, Henriette Alne, Bendik Fyhn Terjesen |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Veterinary (miscellaneous) Salmo salar Administration Oral Aquatic Science Sulfides Lipid peroxidation chemistry.chemical_compound Fish Diseases Random Allocation Lipid oxidation Internal medicine medicine Animals Urea Salmo Muscle Skeletal biology Myositis Myocardium Body Weight Fatty Acids Skeletal muscle Tetradecylthioacetic acid Lipid metabolism Heart biology.organism_classification Lipid Metabolism Survival Analysis Myocarditis medicine.anatomical_structure Endocrinology Blood chemistry chemistry Gene Expression Regulation Infectious pancreatic necrosis |
| Zdroj: | Journal of fish diseases. 32(11) |
| ISSN: | 1365-2761 |
| Popis: | We have previously documented increased survival by feeding tetradecylthioacetic acid (TTA) during a natural outbreak of infectious pancreatic necrosis in post-smolt S1 Atlantic salmon. The aim of the present study was to test the effects of dietary TTA in S0 smolt at a location where fish often experience natural outbreaks of heart and skeletal muscle inflammation (HSMI) during their first spring at sea. The experimental groups were fed a diet supplemented with 0.25% TTA for a 6-week period prior to a natural outbreak of HSMI in May 2007. Relative percent survival for the groups fed TTA was 45% compared with control diets, reducing mortality from 4.7% to 2.5%. Expression of genes related to lipid oxidation was higher in cardiac ventricles from salmon fed TTA compared with controls. In addition, salmon fed TTA had periodically reduced levels of plasma urea, and increased cardiosomatic index and growth. Reduced mortality and increased growth after administration of TTA may be related to a combination of anti-inflammatory effects, and an altered metabolic balance with better protein conservation because of increased lipid degradation. |
| Databáze: | OpenAIRE |
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