The promoter −194 C polymorphism of the nicotinic alpha 7 receptor gene has a protective effect against the P50 sensory gating deficit
| Autor: | Caroline Demily, Dominique Campion, Sadeq Haouzir, Thierry Frebourg, A Belmont, Gaël Fouldrin, Emmanuelle Houy, G Raux, Michel Petit, Gabrielle Allio, Florence Thibaut |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Linkage disequilibrium alpha7 Nicotinic Acetylcholine Receptor Population Gating Receptors Nicotinic Polymerase Chain Reaction Cellular and Molecular Neuroscience Exon medicine Humans Allele Promoter Regions Genetic education Molecular Biology DNA Primers Sequence Deletion Genetics education.field_of_study Polymorphism Genetic Sensory gating Base Sequence biology CHRNA7 Genetic Variation Psychiatry and Mental health medicine.anatomical_structure Endophenotype Sensation Disorders Evoked Potentials Auditory Schizophrenia biology.protein Female Psychology |
| Zdroj: | Molecular Psychiatry. 9:320-322 |
| ISSN: | 1476-5578 1359-4184 |
| DOI: | 10.1038/sj.mp.4001443 |
| Popis: | As suggested by several studies, abnormal sensory gating measured by the P50 paradigm could be an endophenotype predisposing to schizophrenia. In a previous work, we have shown a significant association between the presence of at least one −2 bp deletion located within exon 6 of the CHRNA7-like gene and the P50 abnormality in the general population. A recent study involved polymorphisms located in the core promoter region of the CHRNA7 gene as risk factors for the P50 inhibitory deficit. Screening for promoter variants in a large population of schizophrenic patients (n=111) and control subjects (85), for whom auditory-evoked potentials had been recorded did not allow us to replicate these results. By contrast, we showed a significant association between the −194 C allele and a T/C ratio |
| Databáze: | OpenAIRE |
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