Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques
| Autor: | Louis N. Martin, Peter J. Dailey, Harold M. McClure, Michael F. Greene, Rod Bronson, Timothy W. Baba, Dominique G. Penninck, Nancy B. Ray, Vladimir Liska, Anis H. Khimani, Ruth M. Ruprecht |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Aging Offspring viruses Molecular Sequence Data Simian Acquired Immunodeficiency Syndrome Viremia Disease Biology Vaccines Attenuated medicine.disease_cause Gene Products nef General Biochemistry Genetics and Molecular Biology Acquired immunodeficiency syndrome (AIDS) Pregnancy medicine Animals Pregnancy Complications Infectious Immunity Mucosal Sequence Deletion SAIDS Vaccines Gene Products vpr General Medicine Simian immunodeficiency virus Amniotic Fluid medicine.disease AIDS Vaccines Macaca mulatta Virology Immunology Disease Progression Female Simian Immunodeficiency Virus |
| Zdroj: | Nature Medicine. 5:194-203 |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/5557 |
| Popis: | A substantial risk in using live attenuated, multiply deleted viruses as vaccines against AIDS is their potential to induce AIDS. A mutant of the simian immunodeficiency virus (SIV) with large deletions in nef and vpr and in the negative regulatory element induced AIDS in six of eight infant macaques vaccinated orally or intravenously. Early signs of immune dysfunction were seen in the remaining two offspring. Prolonged follow-up of sixteen vaccinated adult macaques also showed resurgence of chronic viremia in four animals: two of these developed early signs of disease and one died of AIDS. We conclude that this multiply deleted SIV is pathogenic and that human AIDS vaccines built on similar prototypes may cause AIDS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|