POLIOMYELITIS IN GUINEA-PIGS

Autor: M. Neustaedter
Rok vydání: 1913
Předmět:
Zdroj: JAMA: The Journal of the American Medical Association. 60:982
ISSN: 0098-7484
DOI: 10.1001/jama.1913.04340130030013
Popis: P. H. Roemer 2 has noticed that guinea-pigs in his laboratory frequently died of a paralysis which was very similar to that of epidemic poliomyelitis. On studying the cause of this paralysis he found a non-bacterial, filterable virus which could be transmitted from guinea-pig to guinea-pig, and which caused, after an incubation period of nine to twelve days, a flaccid paralysis, usually of the hind legs, with involvement of the bladder. Microscopically this condition also resembled the pathologic picture of poliomyelitis in man. No other investigators report any successful results in this species of animals. Oct. 11, 1912, Monkey 20 ( Macacus rhesus ) was injected with an emulsion of the cord of a monkey that suffered from poliomyelitis of a very high virulence, obtained through the courtesy of Dr. Clark of the Rockefeller Institute. This injected monkey was placed in a cage with a wire bottom. October 14 the animal, which
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