Elevated serum complement C3 levels are associated with prehypertension in an adult population

Autor:	Xiuyang Wang, Huanmin Du, Ge Meng, Hongmei Wu, Liyun Fang, Xing Liu, Guowei Huang, Xing Wang, Xinyu Ma, Peipei Han, Xue Bao, Li Liu, Huijun Yang, Shaomei Sun, Li Kang, Hongbin Shi, Yang Xia, Yeqing Gu, Qi Guo, Renwei Dong, Guolin Wang, Yixuan Ma, Fei Yu, Kun Song, Qiyu Jia, Bin Yu, Ming Zhou, Chunlei Li, Xiaoyan Guo, Qian Su, Qing Zhang, Kaijun Niu
Rok vydání:	2017
Předmět:	Adult Male China medicine.medical_specialty Physiology Adverse outcomes Adult population 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Logistic regression Prehypertension Elevated serum 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Odds Ratio Prevalence Internal Medicine Humans Medicine Inflammation business.industry Public health Complement C3 General Medicine Odds ratio Middle Aged Confidence interval Cross-Sectional Studies Logistic Models Female business
Zdroj:	Clinical and Experimental Hypertension. 39:42-49
ISSN:	1525-6006 1064-1963
DOI:	10.1080/10641963.2016.1210622
Popis:	Prehypertension is a public health epidemic associated with various adverse outcomes, but can be reversed by timely intervention. However, little attention has been paid to prehypertension. Complement C3 is a central hub of complement-related immune system. We examined the association between C3 and prehypertension in an adult population for the first time, aiming to investigate whether pro-inflammatory immune response is involved in the prehypertensive state. About 7820 Tianjin residents without hypertension were categorized into sex-specific quintiles based on their serum concentration of complement C3. Adjusted logistic regression models were used separately by gender to assess the association between C3 quintiles and the prevalence of prehypertension. After multiple adjustment, the odds ratios (95% confidence interval) for prehypertension across increasing quintiles of C3 were 1.00 (reference), 1.02 (0.84, 1.25), 1.15 (0.94, 1.42), 1.25 (1.01, 1.54), and 1.71 (1.35, 2.17) (p for trend < 0.0001) among men and were 1.00 (reference), 1.17 (0.92, 1.49), 1.13 (0.88, 1.44), 1.15 (0.89, 1.48), and 1.40 (1.07, 1.84) (p for trend = 0.03) among women. The findings suggested that elevated serum C3 levels are associated with prehypertension. Reducing inflammation may be a potential therapeutic strategy for prehypertension and hypertension that is worthy of further studies and discussion.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9270f132a12e96764b77dfba7151f6f7 https://doi.org/10.1080/10641963.2016.1210622 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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