Improved Stability and Photodynamic Activity of Water-Soluble 5,15-Diazaporphyrins Incorporated in β-(1,3-1,6)-d-Glucan with On-Off Switch
| Autor: | Atsushi Ikeda, Riku Kawasaki, Shodai Hino, Kazuya Koumoto, Shigeki Kawabata, Takeshi Nagasaki, Toshio Suzuki, Kouta Sugikawa, Hideyuki Shinmori, Shuhei Satake |
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| Rok vydání: | 2019 |
| Předmět: |
Absorption (pharmacology)
chemistry.chemical_classification Liposome Aqueous solution biology 010405 organic chemistry Chemistry Organic Chemistry General Chemistry 010402 general chemistry biology.organism_classification Polysaccharide 01 natural sciences Biochemistry Fluorescence 0104 chemical sciences HeLa Biophysics Intracellular Glucan |
| Zdroj: | Chemistry, an Asian journal. 15(3) |
| ISSN: | 1861-471X |
| Popis: | 5,15-Diazaporphyrins, which have a large absorption at wavelengths over 600 nm, were dissolved in water by complex formation with β-(1,3-1,6)-d-glucans. Aqueous solutions of these complexes were relatively stable compared with their trimethyl-β-cyclodextrin-complexed analogues. β-Glucan-complexed diazaporphyrins showed quenched fluorescence and had low singlet-oxygen-generation abilities owing to random self-aggregation. However, external stimuli, such as the presence of liposomes or intracellular uptake, restored the fluorescence and singlet-oxygen-generation abilities of β-glucan-complexed diazaporphyrins. Consequently, β-glucan-complexed diazaporphyrins showed very high photodynamic activities toward HeLa cells. |
| Databáze: | OpenAIRE |
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