Neurodevelopmental risk factors in schizophrenia

Autor: Eduardo S. Ghisolfi, Betina Teruchkin, Maria Inês Rodrigues Lobato, Paulo Belmonte-de-Abreu, Alexandre Annes Henriques, Daniela Zippin Knijnik
Rok vydání: 2001
Předmět:
Male
medicine.medical_specialty
Physiology
Developmental Disabilities
Immunology
Biophysics
Nutritional Status
Social Environment
Deficiências do desenvolvimento
Biochemistry
Craniofacial Abnormalities
Neurodevelopmental disorder
Pregnancy
Risk Factors
medicine
Humans
risk factors
Minor physical anomalies
Dermatoglyphics
Pregnancy Complications
Infectious
General Pharmacology
Toxicology and Pharmaceutics
Craniofacial
Child
Psychiatry
Anatomia e histologia [Cérebro]
lcsh:QH301-705.5
lcsh:R5-920
Brain Diseases
Fatores de risco
business.industry
General Neuroscience
Social environment
Cell Biology
General Medicine
Etiologia [Esquizofrenia]
medicine.disease
neurodevelopmental disorder
Obstetric Labor Complications
schizophrenia
Increased risk
lcsh:Biology (General)
Schizophrenia
Etiology
Female
Seasons
lcsh:Medicine (General)
business
Zdroj: Brazilian Journal of Medical and Biological Research v.34 n.2 2001
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Volume: 34, Issue: 2, Pages: 155-163, Published: FEB 2001
Brazilian Journal of Medical and Biological Research, Vol 34, Iss 2, Pp 155-163 (2001)
Repositório Institucional da UFRGS
Universidade Federal do Rio Grande do Sul (UFRGS)
instacron:UFRGS
ISSN: 0100-879X
DOI: 10.1590/s0100-879x2001000200002
Popis: The authors review environmental and neurodevelopmental risk factors for schizophrenic disorders, with emphasis on minor physical anomalies, particularly craniofacial anomalies and dermatoglyphic variations. The high prevalence of these anomalies among schizophrenic subjects supports the neurodevelopmental theory of the etiology of schizophrenia, since they suggest either genetically or epigenetically controlled faulty embryonic development of structures of ectodermal origin like brain and skin. This may disturb neurodevelopment that in turn may cause these subjects to be at increased risk for the development of schizophrenia and related disorders. The precise confirmation of this theory, at least in some cases, will provide further understanding of these illnesses, allowing easy and inexpensive identification of subjects at risk and providing guidelines for the development of new pharmacological interventions for early treatment and even for primary prevention of the illness.
Databáze: OpenAIRE
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