Spectral and lifetime resolution of fundus autofluorescence in advanced age-related macular degeneration revealing different signal sources
| Autor: | Somar Hasan, Christine A. Curcio, Rowena Schultz, Daniel Meller, Martin Hammer, Roland T Smith |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Fundus Oculi Retinal Pigment Epithelium Drusen Article Ophthalmoscopy Macular Degeneration Optical coherence tomography Hyperpigmentation Ophthalmology medicine Humans Fluorescein Angiography Retina Retinal pigment epithelium medicine.diagnostic_test business.industry Fundus photography General Medicine Macular degeneration medicine.disease eye diseases medicine.anatomical_structure sense organs medicine.symptom business Tomography Optical Coherence |
| Zdroj: | Acta Ophthalmol |
| ISSN: | 1755-3768 |
| Popis: | PURPOSE To determine the fundus autofluorescence (FAF) lifetimes and spectral characteristics of individual drusen and hyperpigmentation independent of those with retinal pigment epithelium (RPE) in geographic atrophy (GA) areas in late-stage age-related macular degeneration (AMD). METHODS Three consecutive patients with complete RPE and outer retinal atrophy (cRORA) exhibiting drusen that were calcified or associated with hyperpigmentation were investigated with multimodal non-invasive ophthalmic imaging including colour fundus photography (CFP), optical coherence tomography (OCT), near-infrared reflectance (NIR), blue FAF and fluorescence lifetime imaging ophthalmoscopy (FLIO). Fluorescence lifetimes were measured in two spectral channels (short-wavelength spectral channel (SSC): 500-560 nm and long-wavelength spectral channel (LSC): 560-720 nm). RESULTS Drusen lacking RPE coverage, as confirmed by CFP and OCT, had longer FAF lifetimes than surrounding cRORA by 127 ± 66 ps (SSC) and 113 ± 48 ps (LSC, both p = 0.008 in Wilcoxon test, N = 9) and by 209 ± 100 ps (SSC) and 121 ± 56 ps (LSC, p |
| Databáze: | OpenAIRE |
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