Meta-analysis of sex differences in gene expression in schizophrenia
| Autor: | Hui Lu, Monsheel S. Sodhi, Wenyi Qin, Cong Liu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Population Physiology Prefrontal Cortex Biology Postmortem brain 03 medical and health sciences 0302 clinical medicine Sex Factors Structural Biology Modelling and Simulation medicine Humans education Prefrontal cortex Gene Molecular Biology Aged Oligonucleotide Array Sequence Analysis education.field_of_study Applied Mathematics Gene Expression Profiling Microarray analysis Middle Aged medicine.disease Computer Science Applications Gene expression profiling Dorsolateral prefrontal cortex 030104 developmental biology medicine.anatomical_structure Proceedings Schizophrenia Modeling and Simulation Meta-analysis Female Age of onset 030217 neurology & neurosurgery |
| Zdroj: | BMC Systems Biology |
| ISSN: | 1752-0509 |
| Popis: | Schizophrenia is a severe psychiatric disorder which influences around 1 % of the worldwide population. Differences between male and female patients with schizophrenia have been noted. There is an earlier age of onset in males compared with females with this diagnosis, and in addition, there are differences in symptom profiles between the sexes. The underlying molecular mechanism of sex difference remains unclear. Here we present a comprehensive analysis to reveal the sex differences in gene expression in schizophrenia with stringent statistics criteria. We compiled a data set consisting of 89 male controls, 90 male schizophrenia patients, 35 female controls and 32 female schizophrenia patients from six independent studies of the prefrontal cortex (PFC) in postmortem brain. When we tested for a sex by diagnosis interaction on gene expression, 23 genes were up-regulated and 23 genes were down-regulated in the male group (q-value |
| Databáze: | OpenAIRE |
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