Plasma IL-6 levels correlate with clinical and ultrasound measures of arthritis in patients with systemic lupus erythematosus
| Autor: | EM Ball, AL Bell, David Gibson, Rooney |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
medicine.medical_specialty Arthritis Gastroenterology Rheumatology Internal medicine Synovial Fluid Medicine Humans Lupus Erythematosus Systemic In patient B-cell activating factor Interleukin 6 Ultrasonography Hand deformity Systemic lupus erythematosus Tenosynovitis biology business.industry Interleukin-6 Ultrasound Middle Aged medicine.disease Case-Control Studies Immunology biology.protein business Biomarkers |
| Zdroj: | Lupus. 23(1) |
| ISSN: | 1477-0962 |
| Popis: | Objective The objective of this paper is to elucidate the role of specific cytokines in lupus (SLE) arthritis. Methods Fifty SLE and 40 RA patients had an ultrasound (US) scan of their hand as per standardized protocols. US scores were expressed per joint and as a total ‘US activity’ score, (sum of power Doppler (PD) and grey-scale synovial hypertrophy scores in all joints) and a total erosion score. SLE disease activity was assessed (BILAG and SELENA-SLEDAI). Plasma levels of IL-6, TNF-alpha and BLyS were measured using sandwich ELISA kits (Quantikine kits, R & D). Results On the basis of the US results SLE patients were divided into three groups: erosive arthritis ( n = 20), non-erosive arthritis ( n = 18) and those with a normal US scan ( n = 12). Across the SLE groups plasma IL-6 levels correlated with CRP ( p Conclusion This is the first study to examine levels of specific cytokines in a cohort of SLE patients stratified in terms of joint disease by US, where the most significant finding is that IL-6 levels correlated both with clinical and US measures of arthritis disease activity. |
| Databáze: | OpenAIRE |
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