A likelihood ratio test for detecting patterns of disease-marker association
| Autor: | R. N. Curnow, John C. Whittaker, A. P. Morris |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Genetic Markers
Likelihood Functions education.field_of_study Models Genetic Population Association model Genetic Diseases Inborn Disease Biology Linkage Disequilibrium Test (assessment) Diabetes Mellitus Type 1 Likelihood-ratio test Statistics Genetics Humans Allele Child education Association (psychology) Genetics (clinical) Microsatellite Repeats Parametric statistics |
| Zdroj: | Annals of Human Genetics. 61:335-350 |
| ISSN: | 0003-4800 |
| DOI: | 10.1017/s0003480097006349 |
| Popis: | A likelihood ratio test of disease-marker association is proposed, based on the observation of marker alleles transmitted from parents to affected children. The proposed association test has the advantage of identifying the population pattern of disease-marker association, differentiating between marker alleles that are positively and negatively associated with the disease. The power of the test for detecting association is evaluated and compared with three existing multi-allelic tests for some specific disease-marker association patterns. The power of the parametric tests depends crucially on the pattern of disease-marker association. An over-parameterised association model is less detrimental in terms of power than an under parameterised model. |
| Databáze: | OpenAIRE |
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