Homogentisic acid is the product of MelA, which mediates melanogenesis in the marine bacterium Shewanella colwelliana D
| Autor: | Bruce B. Jarvis, S Wang, S. I. Kotob, Ronald M. Weiner, Steven L. Coon, W C Fuqua |
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| Rok vydání: | 1994 |
| Předmět: |
Molecular Sequence Data
medicine.disease_cause Applied Microbiology and Biotechnology 4-Hydroxyphenylpyruvate Dioxygenase Microbiology Gene product chemistry.chemical_compound Biosynthesis Vibrionaceae Gram-Negative Bacteria medicine Seawater Homogentisic acid Amino Acid Sequence Escherichia coli Homogentisic Acid chemistry.chemical_classification Melanins Ecology biology Sequence Homology Amino Acid biology.organism_classification Enzyme chemistry Biochemistry Genes Bacterial Water Microbiology 4-Hydroxyphenylpyruvate dioxygenase Bacteria Food Science Biotechnology Research Article |
| Zdroj: | Applied and environmental microbiology. 60(8) |
| ISSN: | 0099-2240 |
| Popis: | Shewanella colwelliana D is a marine procaryote which produces a diffusible brown pigment that correlates with melA gene expression. Previously, melA had been cloned, sequenced, and expressed in Escherichia coli; however, the reaction product of MelA had not been identified. This report identifies that product as homogentisic acid, provides evidence that the pigment is homogentisic acid-melanin (pyomelanin), and suggests that MelA is p-hydroxyphenylpyruvate hydroxylase. This is the first report of pyomelanin in an obligate marine bacterium. |
| Databáze: | OpenAIRE |
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