Meta-analysis of the association between COL9A2 genetic polymorphisms and lumbar disc disease susceptibility
| Autor: | Zhao-bo Zhang, Jing-sheng Zhang, Xiao Teng, Ling-zhi Ding |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Funnel plot Lumbar Vertebrae business.industry Odds ratio Publication bias Intervertebral Disc Degeneration medicine.disease Polymorphism Single Nucleotide Confidence interval Collagen Type IX Gene Frequency Internal medicine Meta-analysis Genetic model medicine Humans Orthopedics and Sports Medicine Genetic Predisposition to Disease Neurology (clinical) business Allele frequency Lumbar disc disease Alleles |
| Zdroj: | Spine. 39(20) |
| ISSN: | 1528-1159 |
| Popis: | Study design Meta-analysis to collect all the relevant studies to date to further investigate whether or not the COL9A2 gene rs12077871, rs12722877, and rs7533552 polymorphism are associated with susceptibility to lumbar disc disease (LDD). Objective The aim of this study was to assess the association between the COL9A2 gene rs12077871, rs12722877, and rs7533552 and LDD. Summary of background data LDD is a common musculoskeletal disease with strong genetic determinants. COL9A2 encodes the α2 (IX) chain of type IX collagen, which is the major collagen component of the hyaline cartilage. Growing numbers of studies have revealed the association between COL9A2 polymorphisms and susceptibility to LDD. However, those studies have yielded contradictory results. Methods Data were collected from the following electronic databases: PubMed, Web of Knowledge, and China National Knowledge Infrastructure, with the last report up to November 30, 2013. The odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength of association under the allelic genetic model. We summarized the data on the association between COL9A2 rs12077871, rs12722877, and rs7533552 polymorphism and LDD in the overall studies. Results Nine case-control studies, including 1522 LDD cases and 1646 controls, were identified. The results indicated that the rs12077871, rs12722877, and rs7533552 variants in COL9A2 were not associated with LDD (rs12077871: C vs. T, OR = 0.541, 95% CI = 0.256-1.147, P = 0.109; rs12722877: C vs. G, OR = 1.199, 95% CI = 0.992-1.448, P = 0.06; rs7533552: A vs. G, OR = 0.993, 95% CI = 0.815-1.069, P = 0.320). Furthermore, the Egger test and the Begg funnel plot did not show any evidence of publication bias. Conclusion Our results suggest that the COL9A2 rs12077871, rs12722877, and rs7533552 polymorphisms may not be associated with LDD. More studies based on larger sample sizes and homogeneous samples of patients with LDD are needed to confirm these findings. Level of evidence 2. |
| Databáze: | OpenAIRE |
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