Relationship of auditory electrophysiological responses to magnetic resonance spectroscopy metabolites in Early Phase Psychosis
| Autor: | Alan Breier, Brian F. O'Donnell, Andrew Visco, William P. Hetrick, John Barnard, Michael M. Francis, Ruoyun E. Ma, Ulrike Dydak, Nicole F. Mehdiyoun, Andrew M. Wright, Tom A. Hummer, Lisa A. Bartolomeo, Amanda R. Bolbecker |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Psychosis Magnetic Resonance Spectroscopy Adolescent Mismatch negativity Stimulation behavioral disciplines and activities 050105 experimental psychology Article 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Event-related potential Physiology (medical) Choline Medicine Humans 0501 psychology and cognitive sciences Cerebral Cortex business.industry General Neuroscience 05 social sciences Electroencephalography medicine.disease Cortex (botany) Electrophysiology Neuropsychology and Physiological Psychology chemistry Psychotic Disorders Schizophrenia Evoked Potentials Auditory Female business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Int J Psychophysiol International Journal of Psychophysiology |
| ISSN: | 1872-7697 |
| Popis: | Both auditory evoked responses and metabolites measured by magnetic resonance spectroscopy (MRS) are altered in schizophrenia and other psychotic disorders, but the relationship between electrophysiological and metabolic changes are not well characterized. We examined the relation of MRS metabolites to cognitive and electrophysiological measures in individuals during the early phase of psychosis (EPP) and in healthy control subjects. The mismatch negativity (MMN) of the auditory event-related potential to duration deviant tones and the auditory steady response (ASSR) to 40 Hz stimulation were assessed. MRS was used to quantify glutamate+glutamine (Glx), N-Acetylasparate (NAA), creatine (Cre), myo-inositol (Ins) and choline (Cho) at a voxel placed medially in the frontal cortex. MMN amplitude and ASSR power did not differ between groups. The MRS metabolites Glx, Cre and Cho were elevated in the psychosis group. Partial least squares analysis in the patient group indicated that elevated levels of MRS metabolites were associated with reduced MMN amplitude and increased 40 Hz ASSR power. There were no correlations between the neurobiological measures and clinical measures. These data suggest that elevated neurometabolites early in psychosis are accompanied by altered auditory neurotransmission, possibly indicative of a neuroinflammatory or excitotoxic disturbance which disrupts a wide range of metabolic processes in the cortex. |
| Databáze: | OpenAIRE |
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