Membranoproliferative Glomerulonephritis due to Visceral Leishmaniasis in an HIV Patient
| Autor: | Isabel Millán, R. Enríquez, Paula Toro, M.N. Sánchez, Sirvent Ae, Sergio Padilla |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Nephrotic Syndrome Glomerulonephritis Membranoproliferative Biopsy Kidney Glomerulus Nephropathy Diagnosis Differential Glomerulonephritis Membranoproliferative glomerulonephritis medicine Humans Leishmania Miltefosine AIDS-Related Opportunistic Infections business.industry HIV Leishmaniasis General Medicine Articles Middle Aged medicine.disease Dermatology Visceral leishmaniasis Immunology Coinfection Leishmaniasis Visceral business Nephrotic syndrome medicine.drug Membranoproliferative |
| Zdroj: | The American Journal of Case Reports |
| ISSN: | 1941-5923 |
| Popis: | Patient: Male, 47 Final Diagnosis: Membranoproliferative glomerulonephritis Symptoms: Nephrotic syndrome Medication: — Clinical Procedure: Renal biopsy Specialty: Nephrology Objective: Rare disease Background: Visceral leishmaniasis is an important opportunistic disease in HIV-positive patients. The information available on the effects of such co-infection in the kidney is limited. We describe a patient with HIV/leishmania coinfection who developed nephrotic syndrome and membranoproliferative glomerulonephritis. As far as we know, only 2 cases of this nephropathy in HIV/leishmania coinfection have been reported. Case Report: A 47-year-old man developed nephrotic syndrome. He had been diagnosed with HIV infection and visceral leishmaniasis and was treated with antiretroviral therapy, antimonial compounds, liposomal amphotericin B and miltefosine, but the leishmania followed a relapsing course. Renal biopsy disclosed membranoproliferative glomerulonephritis and leishmania amastigotes were seen within glomerular capillary lumens. He was given miltefosine and liposomal amphotericin B but the leishmaniasis persisted. Stage 3B chronic renal disease and nephrotic range proteinuria tend to become stable by 15-month follow-up. Conclusions: Our case illustrated some aspects of leishmaniasis in HIV patients: its relapsing course, the difficulties in therapy, and the renal involvement. |
| Databáze: | OpenAIRE |
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