Administration of a GnRH-antagonist to immature rats affects subsequent female and male pubertal development differently
| Autor: | van Rees Gp, Tilders Fj, van Dieten Ja, van den Dungen Hm, Schoemaker J |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
endocrine system medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism media_common.quotation_subject Fertility Gonadotropin-Releasing Hormone Endocrinology Internal medicine medicine Animals Testosterone Sexual Maturation Ovulation media_common Estrous cycle business.industry GnRH Antagonist Age Factors Antagonist Rats Inbred Strains General Medicine Luteinizing Hormone Rats Gonadotropin secretion Female Follicle Stimulating Hormone Gonadotropin business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Acta Endocrinologica. 120:778-784 |
| ISSN: | 1479-683X 0804-4643 |
| DOI: | 10.1530/acta.0.1200778 |
| Popis: | Gonadotropin secretion was inhibited in immature male and female rats by sc administration of the GnRH-antagonist ORG30276 (GnRH-A) on days 6, 9, 12 and 15. In GnRH-A-treated females this resulted in suppression of the temporarily increased plasma LH and FSH levels, which normally occur in prepubertal female rats. Ovarian weight was decreased. Although vaginal opening in GnRH-A-treated rats occurred earlier, the age of 1st estrus and the number of ova shed at first ovulation were not affected. Fertility at 4 months of age was normal. After initial suppression of gonadotropin levels, the FSH levels in GnRH-A-treated males, however, sharply increased to about twice the control levels. Plasma FSH remained elevated at least until 4 months of age. The LH levels at adult age were not affected by antagonist treatment and neither were testosterone levels. Testicular weight was decreased by GnRH-A from about 50% on day 15 to about 30% at 4 months of age. Pubertal development as measured by balano-preputial separation was delayed by about 7–10 days. At 4 months of age fertility was decreased. Thus, suppression of early gonadotropin secretion by GnRH-A treatment had dramatic effects on subsequent pubertal development in the male, but not in the female rat. |
| Databáze: | OpenAIRE |
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